Spesp1 sperm equatorial segment protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spesp1provided by RGD
Official Full Name: sperm equatorial segment protein 1provided by RGD
Primary source: RGD:1563468
See related: EnsemblRapid:ENSRNOG00000025359 AllianceGenome:RGD:1563468
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563468
Summary: Predicted to be involved in acrosome reaction; fusion of sperm to egg plasma membrane involved in single fertilization; and sperm-egg recognition. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in acrosomal vesicle. Orthologous to human SPESP1 (sperm equatorial segment protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 858.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (71646806..71662219, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (62751313..62766657, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (67217801..67233172, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in acrosome reaction	IBA Inferred from Biological aspect of Ancestor more info
involved_in acrosome reaction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in fertilization	ISO Inferred from Sequence Orthology more info
involved_in fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fusion of sperm to egg plasma membrane involved in single fertilization	ISO Inferred from Sequence Orthology more info
involved_in sperm-egg recognition	ISO Inferred from Sequence Orthology more info
involved_in sperm-egg recognition	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sperm equatorial segment protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077682.1 → NP_001071150.1 sperm equatorial segment protein 1 precursor

See identical proteins and their annotated locations for NP_001071150.1

Status: PROVISIONAL

Source sequence(s)

BC127527

UniProtKB/Swiss-Prot

A0JPP4

UniProtKB/TrEMBL

A6J575

Related

ENSRNOP00000043936.3, ENSRNOT00000049441.5

Conserved Domains (1) summary

pfam15754
Location:21 → 381

SPESP1; Sperm equatorial segment protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

71646806..71662219 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243210.5 → XP_006243272.1 sperm equatorial segment protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A6I5

Related

ENSRNOP00000086706.1, ENSRNOT00000116693.2

Conserved Domains (1) summary

pfam15754
Location:18 → 378

SPESP1; Sperm equatorial segment protein 1