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    Tf transferrin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24825, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tfprovided by RGD
    Official Full Name
    transferrinprovided by RGD
    Primary source
    RGD:3845
    See related
    EnsemblRapid:ENSRNOG00000030625 AllianceGenome:RGD:3845
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tfn; Trf
    Summary
    Enables ferric iron binding activity. Involved in several processes, including cellular response to cAMP; cellular response to follicle-stimulating hormone stimulus; and regulation of nervous system development. Located in several cellular components, including basement membrane; cell tip; and dendrite. Used to study hepatitis. Biomarker of anemia and obesity. Human ortholog(s) of this gene implicated in anemia (multiple); atransferrinemia; gastrointestinal system disease; glucose metabolism disease (multiple); and restless legs syndrome. Orthologous to human TF (transferrin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 154751.8) See more
    Orthologs
    NEW
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    Genomic context

    Location:
    8q32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112668667..112695376, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (103789780..103816487, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111694570..111721275, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene RAB6B, member RAS oncogene family Neighboring gene uncharacterized LOC134480222 Neighboring gene SRP receptor subunit beta Neighboring gene uncharacterized LOC134480223 Neighboring gene uncharacterized LOC134480224 Neighboring gene uncharacterized LOC120094247 Neighboring gene inhibitor of carbonic anhydrase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: Srprb

    Clone Names

    • MGC93500

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ferric iron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron chaperone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acute-phase response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to follicle-stimulating hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to iron ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular iron ion homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in iron ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in iron ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within iron ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in multicellular organismal-level iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myelination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of oligodendrocyte progenitor proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of iron ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of HFE-transferrin receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dense body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of vesicle coat ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serotransferrin
    Names
    beta-1 metal-binding globulin
    liver regeneration-related protein LRRG03
    siderophilin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013110.1NP_001013128.1  serotransferrin precursor

      See identical proteins and their annotated locations for NP_001013128.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087021
      UniProtKB/Swiss-Prot
      P12346, Q63602, Q64628, Q64630, Q7TNX0
      UniProtKB/TrEMBL
      A6I2I8, A6I2I9
      Related
      ENSRNOP00000045637.2, ENSRNOT00000045628.7
      Conserved Domains (4) summary
      smart00094
      Location:360683
      TR_FER; Transferrin
      cd13617
      Location:357682
      PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
      cd13618
      Location:24346
      PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
      pfam00405
      Location:25347
      Transferrin; Transferrin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      112668667..112695376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)