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    Hemk1 HemK methyltransferase family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300989, updated on 27-Dec-2024

    Summary

    Official Symbol
    Hemk1provided by RGD
    Official Full Name
    HemK methyltransferase family member 1provided by RGD
    Primary source
    RGD:1308293
    See related
    EnsemblRapid:ENSRNOG00000015458 AllianceGenome:RGD:1308293
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308293
    Summary
    Predicted to enable protein-(glutamine-N5) methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in mitochondrion. Orthologous to human HEMK1 (HemK methyltransferase family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 40.2), Kidney (RPKM 31.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hemk1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (116878317..116889342, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107999658..108010732, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116081858..116092872, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA, pseudogene 9 Neighboring gene cytokine inducible SH2-containing protein Neighboring gene similar to human chromosome 3 open reading frame 18 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 2 Neighboring gene uncharacterized LOC134480230

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in methylation  
    Component Evidence Code Pubs
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    MTRF1L release factor glutamine methyltransferase
    NP_001100323.1
    XP_006243790.1
    XP_006243791.1
    XP_006243792.1
    XP_038937143.1
    XP_038937144.1
    XP_063121308.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106853.1 → NP_001100323.1  MTRF1L release factor glutamine methyltransferase

      See identical proteins and their annotated locations for NP_001100323.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A0A8I6ADD7, A6I2W7, B1WBZ2, F7F513
      Related
      ENSRNOP00000020781.4, ENSRNOT00000020781.8
      Conserved Domains (2) summary
      TIGR03534
      Location:64 → 333
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
      cl17173
      Location:91 → 300
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      116878317..116889342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243730.5 → XP_006243792.1  MTRF1L release factor glutamine methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006243792.1

      UniProtKB/TrEMBL
      A0A8I6ADD7, A6I2W7, B1WBZ2, F7F513
      Conserved Domains (2) summary
      TIGR03534
      Location:64 → 333
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
      cl17173
      Location:91 → 300
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_006243729.5 → XP_006243791.1  MTRF1L release factor glutamine methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006243791.1

      UniProtKB/TrEMBL
      A0A8I6ADD7, A6I2W7, B1WBZ2, F7F513
      Conserved Domains (2) summary
      TIGR03534
      Location:64 → 333
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
      cl17173
      Location:91 → 300
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_006243728.4 → XP_006243790.1  MTRF1L release factor glutamine methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006243790.1

      UniProtKB/TrEMBL
      A0A8I6ADD7, A6I2W7, B1WBZ2, F7F513
      Conserved Domains (2) summary
      TIGR03534
      Location:64 → 333
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
      cl17173
      Location:91 → 300
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. XM_039081215.2 → XP_038937143.1  MTRF1L release factor glutamine methyltransferase isoform X2

      Conserved Domains (1) summary
      TIGR03534
      Location:1 → 225
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
    5. XM_039081216.1 → XP_038937144.1  MTRF1L release factor glutamine methyltransferase isoform X2

      Conserved Domains (1) summary
      TIGR03534
      Location:1 → 225
      RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
    6. XM_063265238.1 → XP_063121308.1  MTRF1L release factor glutamine methyltransferase isoform X3

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