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    Klc4 kinesin light chain 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klc4provided by RGD
    Official Full Name
    kinesin light chain 4provided by RGD
    Primary source
    RGD:1306555
    See related
    EnsemblRapid:ENSRNOG00000018168 AllianceGenome:RGD:1306555
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Knsl8; 1200014p03rik
    Summary
    Predicted to enable kinesin binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in microtubule. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm. Orthologous to human KLC4 (kinesin light chain 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 291.5), Heart (RPKM 143.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klc4 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21834765..21848676)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14337164..14351075)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16647577..16661463)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cullin 7 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene protein tyrosine kinase 7 Neighboring gene uncharacterized LOC120094784

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94745

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin light chain 4
    Names
    KLC 4
    kinesin-like 8
    kinesin-like protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009601.2 → NP_001009601.1  kinesin light chain 4

      See identical proteins and their annotated locations for NP_001009601.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5PQM2
      UniProtKB/TrEMBL
      A6JIQ2
      Related
      ENSRNOP00000038363.3, ENSRNOT00000031625.5
      Conserved Domains (3) summary
      TIGR02168
      Location:33 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295 → 323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294 → 369
      TPR_12; Tetratricopeptide repeat

    2. NM_001432593.1 → NP_001419522.1  kinesin light chain 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5PQM2
      UniProtKB/TrEMBL
      A6JIQ2

    3. NM_001432594.1 → NP_001419523.1  kinesin light chain 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5PQM2
      UniProtKB/TrEMBL
      A6JIQ2

    4. NM_001432595.1 → NP_001419524.1  kinesin light chain 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5PQM2
      UniProtKB/TrEMBL
      A6JIQ2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21834765..21848676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083506.1 → XP_038939434.1  kinesin light chain 4 isoform X2

      Conserved Domains (2) summary
      TIGR02168
      Location:33 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13424
      Location:210 → 264
      TPR_12; Tetratricopeptide repeat

    2. XM_006244516.5 → XP_006244578.1  kinesin light chain 4 isoform X1

      Conserved Domains (3) summary
      TIGR02168
      Location:33 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295 → 323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294 → 369
      TPR_12; Tetratricopeptide repeat

    3. XM_006244517.4 → XP_006244579.1  kinesin light chain 4 isoform X1

      Conserved Domains (3) summary
      TIGR02168
      Location:33 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295 → 323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294 → 369
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQM2.1 GenPept UniProtKB/Swiss-Prot:Q5PQM2

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