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    Frmpd4 FERM and PDZ domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302656, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Frmpd4provided by RGD
    Official Full Name
    FERM and PDZ domain containing 4provided by RGD
    Primary source
    RGD:1566031
    See related
    EnsemblRapid:ENSRNOG00000004118 AllianceGenome:RGD:1566031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566031
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Involved in postsynaptic actin cytoskeleton organization. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 104. Orthologous to human FRMPD4 (FERM and PDZ domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 140.2) and Lung (RPKM 6.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Frmpd4 in Genome Data Viewer
    Location:
    Xq13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (29739834..30386917)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (25853849..26814642)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (27231648..28206890)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene MSL complex subunit 3 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene FANCD2 opposite strand like 2 Neighboring gene FANCD2 opposite strand like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Downregulation of Preso protects against ischemic/reperfusion-mediated neuronal injury through regulating PSD95-nNOS/YAP pathways. Chen R, et al. Neurochem Int, 2023 Oct. PMID 37442439
    2. Preso1 dynamically regulates group I metabotropic glutamate receptors. Hu JH, et al. Nat Neurosci, 2012 Jun. PMID 22561452, Free PMC Article
    3. Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. Lee HW, et al. J Neurosci, 2008 Dec 31. PMID 19118189, Free PMC Article
    4. Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). Yuzawa S, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22074847, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of Preso protects against ischemic/reperfusion-mediated neuronal injury through regulating PSD95-nNOS/YAP pathways.
      Title: Downregulation of Preso protects against ischemic/reperfusion-mediated neuronal injury through regulating PSD95-nNOS/YAP pathways.
    2. We identified and cloned a full-length gene determined to be homologous to human FRMPD4 and is here termed Preso1.
      Title: Preso1 dynamically regulates group I metabotropic glutamate receptors.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of synapse structural plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynaptic actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FERM and PDZ domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106960.2 → NP_001100430.2  FERM and PDZ domain-containing protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D4A3K7
      Related
      ENSRNOP00000093782.2, ENSRNOT00000104697.2

    2. NM_001434010.1 → NP_001420939.1  FERM and PDZ domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6ALF4

    3. NM_001434011.1 → NP_001420940.1  FERM and PDZ domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D4A3K7

    4. NM_001434012.1 → NP_001420941.1  FERM and PDZ domain-containing protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    5. NM_001434013.1 → NP_001420942.1  FERM and PDZ domain-containing protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D4A3K7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      29739834..30386917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601999.3 → XP_017457488.1  FERM and PDZ domain-containing protein 4 isoform X3

    2. XM_063279932.1 → XP_063136002.1  FERM and PDZ domain-containing protein 4 isoform X6

      Related
      ENSRNOP00000089628.1, ENSRNOT00000112961.2

    3. XM_039099649.2 → XP_038955577.1  FERM and PDZ domain-containing protein 4 isoform X4

      Conserved Domains (6) summary
      smart00295
      Location:197 → 416
      B41; Band 4.1 homologues
      cd00201
      Location:28 → 57
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:68 → 144
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13183
      Location:412 → 516
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd17170
      Location:193 → 286
      FERM_F1_FRMPD4; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 4 (FRMPD4)
      cd21943
      Location:965 → 1013
      LGNbd_FRMPD4; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 4

    4. XM_063279930.1 → XP_063136000.1  FERM and PDZ domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      D4A3K7

    5. XM_017602000.3 → XP_017457489.1  FERM and PDZ domain-containing protein 4 isoform X4

      Conserved Domains (6) summary
      smart00295
      Location:197 → 416
      B41; Band 4.1 homologues
      cd00201
      Location:28 → 57
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:68 → 144
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13183
      Location:412 → 516
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd17170
      Location:193 → 286
      FERM_F1_FRMPD4; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 4 (FRMPD4)
      cd21943
      Location:965 → 1013
      LGNbd_FRMPD4; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 4

    6. XM_017601998.3 → XP_017457487.1  FERM and PDZ domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALA6, D4A3K7
      Related
      ENSRNOP00000094044.1, ENSRNOT00000096626.2

    7. XM_063279931.1 → XP_063136001.1  FERM and PDZ domain-containing protein 4 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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