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    Bmx BMX non-receptor tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367786, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Bmxprovided by RGD
    Official Full Name
    BMX non-receptor tyrosine kinaseprovided by RGD
    Primary source
    RGD:1565643
    See related
    EnsemblRapid:ENSRNOG00000003705 AllianceGenome:RGD:1565643
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565643
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in B cell receptor signaling pathway; adaptive immune response; and protein autophosphorylation. Predicted to be located in nucleoplasm and ruffle membrane. Predicted to be active in plasma membrane. Orthologous to human BMX (BMX non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 13.7), Heart (RPKM 9.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bmx in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (33859128..33921876)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (30227251..30290015)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (31976231..32046326)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene pirin Neighboring gene small nucleolar RNA SNORA48 Neighboring gene U6 spliceosomal RNA Neighboring gene cytochrome c oxidase assembly factor 5, pseudogene 1 Neighboring gene angiotensin converting enzyme 2 Neighboring gene collectrin, amino acid transport regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Location and level of Etk expression in neurons are associated with varied severity of traumatic brain injury. Wu JC, et al. PLoS One, 2012. PMID 22723969, Free PMC Article
    2. Suppression of Etk/Bmx protects against ischemic brain injury. Chen KY, et al. Cell Transplant, 2012. PMID 21929872
    3. Sodium and potassium regulate endothelial phospholipase C-γ and Bmx. Ying WZ, et al. Am J Physiol Renal Physiol, 2014 Jul 1. PMID 24785188, Free PMC Article
    4. Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Chen R, et al. Nat Cell Biol, 2001 May. PMID 11331870
    5. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. Tsai YT, et al. Mol Cell Biol, 2000 Mar. PMID 10688651, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effects of dietary K(+) on Bmx were more pronounced
      Title: Sodium and potassium regulate endothelial phospholipase C-γ and Bmx.
    2. Location and level of Etk expression in neurons are associated with varied severity of traumatic brain injury
      Title: Location and level of Etk expression in neurons are associated with varied severity of traumatic brain injury.
    3. data suggest that Etk/Bmx is activated after neuronal injury; suppressing Etk activity protects against neurodegeneration in ischemic brain
      Title: Suppression of Etk/Bmx protects against ischemic brain injury.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic tyrosine-protein kinase BMX
    NP_001102486.1
    XP_038955871.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109016.1 → NP_001102486.1  cytoplasmic tyrosine-protein kinase BMX

      See identical proteins and their annotated locations for NP_001102486.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474014
      UniProtKB/TrEMBL
      A6K2L5, F1LVI0
      Related
      ENSRNOP00000005181.8, ENSRNOT00000005181.9
      Conserved Domains (5) summary
      cd10399
      Location:269 → 374
      SH2_Tec_Bmx; Src homology 2 (SH2) domain found in Tec protein, Bmx
      cd01238
      Location:25 → 151
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      pfam00169
      Location:27 → 115
      PH; PH domain
      pfam07714
      Location:397 → 646
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:392 → 647
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      33859128..33921876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099943.2 → XP_038955871.1  cytoplasmic tyrosine-protein kinase BMX isoform X1

      Conserved Domains (3) summary
      cd10399
      Location:265 → 370
      SH2_Tec_Bmx; Src homology 2 (SH2) domain found in Tec protein, Bmx
      cd01238
      Location:21 → 147
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      cl21453
      Location:388 → 643
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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