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    Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84351, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ikbkbprovided by RGD
    Official Full Name
    inhibitor of nuclear factor kappa B kinase subunit betaprovided by RGD
    Primary source
    RGD:621375
    See related
    EnsemblRapid:ENSRNOG00000019073 AllianceGenome:RGD:621375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IKK2; AIM-1
    Summary
    Enables ATP binding activity. Contributes to IkappaB kinase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; response to cholecystokinin; and response to lipopolysaccharide. Part of IkappaB kinase complex. Used to study muscular atrophy and pneumonia. Biomarker of Alzheimer's disease; colitis; colon cancer; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 138.6), Thymus (RPKM 121.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ikbkb in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (76021968..76075717)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69319487..69373251)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74177233..74230809)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482521 Neighboring gene adaptor related protein complex 3 subunit mu 2 Neighboring gene plasminogen activator, tissue type Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene DNA polymerase beta Neighboring gene dickkopf WNT signaling pathway inhibitor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 46
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    contributes_to IkappaB kinase activity  
    contributes_to IkappaB kinase activity PubMed 
    enables IkappaB kinase activity  
    enables IkappaB kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase activity  
    enables protein kinase activity  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein phosphatase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding PubMed 
    enables ribosomal protein S6 kinase activity  
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables transferrin receptor binding  
    enables transferrin receptor binding  
    Items 1 - 25 of 46
    Items 1 - 25 of 43
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell homeostasis  
    involved_in canonical NF-kappaB signal transduction  
    involved_in canonical NF-kappaB signal transduction  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in chromatin remodeling  
    involved_in integrin-mediated signaling pathway  
    involved_in interleukin-1-mediated signaling pathway  
    involved_in interleukin-1-mediated signaling pathway  
    involved_in negative regulation of bicellular tight junction assembly  
    involved_in negative regulation of bicellular tight junction assembly  
    involved_in neuron projection development PubMed 
    involved_in peptidyl-serine phosphorylation  
    involved_in positive regulation of NF-kappaB transcription factor activity PubMed 
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within positive regulation of cation channel activity  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of neuron projection development PubMed 
    acts_upstream_of_or_within positive regulation of sodium ion transport  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in protein maturation  
    involved_in protein maturation  
    involved_in protein phosphorylation  
    involved_in regulation of establishment of endothelial barrier  
    involved_in regulation of establishment of endothelial barrier  
    involved_in regulation of phosphorylation  
    involved_in response to cholecystokinin PubMed 
    involved_in response to fatty acid PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to toxic substance PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in skeletal muscle contraction PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in tumor necrosis factor-mediated signaling pathway  
    Items 1 - 25 of 43
    Component Evidence Code Pubs
    part_of CD40 receptor complex  
    part_of IkappaB kinase complex  
    part_of IkappaB kinase complex PubMed 
    part_of IkappaB kinase complex  
    part_of IkappaB kinase complex  
    is_active_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasmic side of plasma membrane  
    located_in cytosol  
    located_in membrane raft  
    located_in nucleus  

    General protein information

    Preferred Names
    inhibitor of nuclear factor kappa-B kinase subunit beta
    Names
    I-kappa-B kinase 2
    I-kappa-B-kinase beta
    IKK-B
    IKK-beta
    NFKBIKB
    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    inhibitor of kappaB kinase beta
    inhibitor of nuclear factor kappa B kinase beta subunit
    nuclear factor NF-kappa-B inhibitor kinase beta
    serine/threonine protein kinase IKBKB
    NP_445807.2
    XP_038950795.1
    XP_063131856.1
    XP_063131857.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053355.3NP_445807.2  inhibitor of nuclear factor kappa-B kinase subunit beta

      See identical proteins and their annotated locations for NP_445807.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q9QY78
      UniProtKB/TrEMBL
      A6IW61, G3V8H5
      Related
      ENSRNOP00000025851.2, ENSRNOT00000025851.6
      Conserved Domains (4) summary
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
      cd17046
      Location:310390
      Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
      pfam12179
      Location:708742
      IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
      pfam18397
      Location:389663
      IKBKB_SDD; IQBAL scaffold dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      76021968..76075717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275786.1XP_063131856.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1

      UniProtKB/Swiss-Prot
      Q9QY78
      Related
      ENSRNOP00000112638.1, ENSRNOT00000154195.1
    2. XM_063275787.1XP_063131857.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2

    3. XM_039094867.2XP_038950795.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3

      Conserved Domains (2) summary
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
      cd17046
      Location:310390
      Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
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