U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    S1pr5 sphingosine-1-phosphate receptor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60399, updated on 9-Dec-2024

    Summary

    Official Symbol
    S1pr5provided by RGD
    Official Full Name
    sphingosine-1-phosphate receptor 5provided by RGD
    Primary source
    RGD:620566
    See related
    EnsemblRapid:ENSRNOG00000020901 AllianceGenome:RGD:620566
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Edg8; Edg-8
    Summary
    Enables G protein-coupled receptor activity. Involved in regulation of neuron differentiation. Predicted to be active in cytoplasm; plasma membrane; and presynapse. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 55.0), Lung (RPKM 18.2) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See S1pr5 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28062841..28068013, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19786676..19791862, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22268635..22273708, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4A Neighboring gene uncharacterized LOC134480144 Neighboring gene Kelch-like ECH-associated protein 1 Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog Neighboring gene cyclin dependent kinase inhibitor 2D

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in plasma membrane  
    is_active_in presynapse  

    General protein information

    Preferred Names
    sphingosine 1-phosphate receptor 5
    Names
    NRG-1
    S1P receptor 5
    S1P receptor Edg-8
    S1P5
    endothelial differentiation G-protein-coupled receptor 8
    endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
    nerve growth factor-regulated G-protein-coupled receptor 1
    sphingosine 1-phosphate receptor Edg-8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021775.2NP_068543.2  sphingosine 1-phosphate receptor 5

      See identical proteins and their annotated locations for NP_068543.2

      Status: PROVISIONAL

      Source sequence(s)
      AF115249
      UniProtKB/Swiss-Prot
      Q9JKM5
      Related
      ENSRNOP00000090421.1, ENSRNOT00000098087.2
      Conserved Domains (1) summary
      pfam00001
      Location:53307
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28062841..28068013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242663.5XP_006242725.1  sphingosine 1-phosphate receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006242725.1

      UniProtKB/Swiss-Prot
      Q9JKM5, Q9QY79
      UniProtKB/TrEMBL
      A6JNQ5
      Related
      ENSRNOP00000101555.1, ENSRNOT00000155578.1
      Conserved Domains (2) summary
      cd14964
      Location:3864
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:37318
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_006242665.5XP_006242727.1  sphingosine 1-phosphate receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006242727.1

      UniProtKB/Swiss-Prot
      Q9JKM5, Q9QY79
      UniProtKB/TrEMBL
      A6JNQ5
      Related
      ENSRNOP00000028380.3, ENSRNOT00000028380.7
      Conserved Domains (2) summary
      cd14964
      Location:3864
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:37318
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_006242664.5XP_006242726.1  sphingosine 1-phosphate receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006242726.1

      UniProtKB/Swiss-Prot
      Q9JKM5, Q9QY79
      UniProtKB/TrEMBL
      A6JNQ5
      Conserved Domains (2) summary
      cd14964
      Location:3864
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:37318
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    External link. Please review our privacy policy.