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    Rab27b RAB27B, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84590, updated on 9-Dec-2024

    Summary

    Symbol
    Rab27bprovided by RGD
    Full Name
    RAB27B, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:620114
    See related
    EnsemblRapid:ENSRNOG00000012176 AllianceGenome:RGD:620114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in anterograde axonal protein transport; regulation of exocytosis; and synaptic vesicle endocytosis. Located in apical plasma membrane and zymogen granule membrane. Is active in synaptic vesicle membrane. Orthologous to human RAB27B (RAB27B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 111.5), Spleen (RPKM 81.5) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Rab27b in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (65870230..66069597, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (63597554..63794124, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (68486006..68644595, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482985 Neighboring gene coiled-coil domain containing 68 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120098183

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity  
    enables GDP binding  
    enables GDP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables membrane scission GTPase motor activity  
    enables myosin V binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi stack  
    is_active_in apical plasma membrane  
    located_in apical plasma membrane PubMed 
    located_in axon cytoplasm  
    is_active_in exocytic vesicle  
    located_in late endosome  
    located_in late endosome  
    is_active_in melanosome  
    located_in melanosome  
    located_in membrane  
    located_in multivesicular body membrane  
    is_active_in secretory granule  
    is_active_in synaptic vesicle membrane PubMed 
    is_active_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane PubMed 
    located_in trans-Golgi network transport vesicle  
    located_in zymogen granule membrane PubMed 

    General protein information

    Preferred Names
    ras-related protein Rab-27B
    NP_445911.1
    XP_006254992.1
    XP_017456535.1
    XP_038953121.1
    XP_038953122.1
    XP_038953123.1
    XP_038953127.1
    XP_063133705.1
    XP_063133706.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053459.1NP_445911.1  ras-related protein Rab-27B

      See identical proteins and their annotated locations for NP_445911.1

      Status: PROVISIONAL

      Source sequence(s)
      AF325693
      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
      Related
      ENSRNOP00000095120.1, ENSRNOT00000106463.2
      Conserved Domains (1) summary
      cd04127
      Location:6185
      Rab27A; Rab GTPase family 27a (Rab27a)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      65870230..66069597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097195.2XP_038953123.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
      Conserved Domains (1) summary
      cd04127
      Location:6185
      Rab27A; Rab GTPase family 27a (Rab27a)
    2. XM_063277636.1XP_063133706.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
    3. XM_063277635.1XP_063133705.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
    4. XM_006254930.5XP_006254992.1  ras-related protein Rab-27B isoform X1

      See identical proteins and their annotated locations for XP_006254992.1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
      Conserved Domains (1) summary
      cd04127
      Location:6185
      Rab27A; Rab GTPase family 27a (Rab27a)
    5. XM_039097193.2XP_038953121.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
      Conserved Domains (1) summary
      cd04127
      Location:6185
      Rab27A; Rab GTPase family 27a (Rab27a)
    6. XM_039097194.2XP_038953122.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
      Conserved Domains (1) summary
      cd04127
      Location:6185
      Rab27A; Rab GTPase family 27a (Rab27a)
    7. XM_017601046.3XP_017456535.1  ras-related protein Rab-27B isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q7R9
      Related
      ENSRNOP00000016369.2, ENSRNOT00000016369.5
    8. XM_039097199.2XP_038953127.1  ras-related protein Rab-27B isoform X3

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