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    Mtx3 metaxin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtx3provided by RGD
    Official Full Name
    metaxin 3provided by RGD
    Primary source
    RGD:1583002
    See related
    EnsemblRapid:ENSRNOG00000075938 AllianceGenome:RGD:1583002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrion. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Orthologous to human MTX3 (metaxin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 82.3), Kidney (RPKM 58.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtx3 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (25800530..25814755)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (24066332..24079708)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (22427453..22440813)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene serine incorporator 5 Neighboring gene thrombospondin 4 Neighboring gene uncharacterized LOC108350222 Neighboring gene uncharacterized LOC134485815

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SAM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metaxin 3; metaxin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433247.1 → NP_001420176.1  metaxin 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I4R8, D3ZNK1

    2. NM_001433248.1 → NP_001420177.1  metaxin 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I4R8

    3. NM_001433249.1 → NP_001420178.1  metaxin 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      25800530..25814755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003749167.6 → XP_003749215.1  metaxin-3 isoform X1

      See identical proteins and their annotated locations for XP_003749215.1

      UniProtKB/TrEMBL
      A6I4R8, D3ZNK1
      Related
      ENSRNOP00000107817.1, ENSRNOT00000125152.1
      Conserved Domains (2) summary
      cd03212
      Location:105 → 241
      GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
      pfam10568
      Location:23 → 142
      Tom37; Outer mitochondrial membrane transport complex protein

    2. XM_006231788.5 → XP_006231850.1  metaxin-3 isoform X2

      See identical proteins and their annotated locations for XP_006231850.1

      UniProtKB/TrEMBL
      A6I4R8
      Conserved Domains (2) summary
      cd03212
      Location:105 → 241
      GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
      cd03078
      Location:5 → 77
      GST_N_Metaxin1_like; GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the ...

    3. XM_063282830.1 → XP_063138900.1  metaxin-3 isoform X4

      UniProtKB/TrEMBL
      A6I4R8

    4. XM_063282829.1 → XP_063138899.1  metaxin-3 isoform X3

      UniProtKB/TrEMBL
      A6I4R8

    5. XM_039103450.2 → XP_038959378.1  metaxin-3 isoform X5

      Conserved Domains (2) summary
      pfam10568
      Location:23 → 142
      Tom37; Outer mitochondrial membrane transport complex protein
      cl02776
      Location:105 → 195
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    RNA

    1. XR_005500503.2 RNA Sequence

    2. XR_351276.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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