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    Adgrb2 adhesion G protein-coupled receptor B2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313058, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Adgrb2provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor B2provided by RGD
    Primary source
    RGD:1309431
    See related
    EnsemblRapid:ENSRNOG00000014375 AllianceGenome:RGD:1309431
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bai2
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; calcineurin-NFAT signaling cascade; and peripheral nervous system development. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in extracellular region. Predicted to be active in glutamatergic synapse and plasma membrane. Orthologous to human ADGRB2 (adhesion G protein-coupled receptor B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 160.2), Muscle (RPKM 67.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgrb2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (147581573..147646726)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (142299190..142362540)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (148168530..148231587)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486996 Neighboring gene SPOC domain containing 1 Neighboring gene collagen type XVI alpha 1 chain Neighboring gene uncharacterized LOC120102987 Neighboring gene penta-EF hand domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity. Purcell RH, et al. Hum Mutat, 2017 Dec. PMID 28891236, Free PMC Article
    2. Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. Kee HJ, et al. J Cereb Blood Flow Metab, 2002 Sep. PMID 12218411
    3. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peripheral nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peripheral nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor B2
    Names
    brain-specific angiogenesis inhibitor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107914.1 → NP_001101384.1  adhesion G protein-coupled receptor B2 precursor

      See identical proteins and their annotated locations for NP_001101384.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A0A8I6GF79, A6ISM9, D3ZN99
      Related
      ENSRNOP00000060321.1, ENSRNOT00000064948.3
      Conserved Domains (5) summary
      smart00303
      Location:863 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:521 → 585
      HormR; Domain present in hormone receptors
      smart00209
      Location:357 → 407
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:922 → 1191
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:605 → 762
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      147581573..147646726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238935.5 → XP_006238997.1  adhesion G protein-coupled receptor B2 isoform X2

      See identical proteins and their annotated locations for XP_006238997.1

      UniProtKB/TrEMBL
      A0A8I6GF79, A6ISM9, D3ZN99
      Conserved Domains (5) summary
      smart00303
      Location:863 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:521 → 585
      HormR; Domain present in hormone receptors
      smart00209
      Location:357 → 407
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:922 → 1191
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:605 → 762
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    2. XM_006238934.3 → XP_006238996.1  adhesion G protein-coupled receptor B2 isoform X2

      See identical proteins and their annotated locations for XP_006238996.1

      UniProtKB/TrEMBL
      A0A8I6GF79, A6ISM9, D3ZN99
      Conserved Domains (5) summary
      smart00303
      Location:863 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:521 → 585
      HormR; Domain present in hormone receptors
      smart00209
      Location:357 → 407
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:922 → 1191
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:605 → 762
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    3. XM_017593334.1 → XP_017448823.1  adhesion G protein-coupled receptor B2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GF79
      Conserved Domains (5) summary
      smart00303
      Location:863 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:521 → 585
      HormR; Domain present in hormone receptors
      smart00209
      Location:357 → 407
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:922 → 1191
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:605 → 762
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    4. XM_017593335.1 → XP_017448824.1  adhesion G protein-coupled receptor B2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K6N2, A0A8I6GF79
      Related
      ENSRNOP00000073878.2, ENSRNOT00000088568.3
      Conserved Domains (5) summary
      smart00303
      Location:863 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:521 → 585
      HormR; Domain present in hormone receptors
      smart00209
      Location:357 → 407
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:922 → 1158
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:605 → 762
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    5. XM_017593336.1 → XP_017448825.1  adhesion G protein-coupled receptor B2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GF79
      Conserved Domains (5) summary
      smart00303
      Location:863 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:521 → 585
      HormR; Domain present in hormone receptors
      smart00209
      Location:357 → 407
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:922 → 1158
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:605 → 762
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    6. XM_017593338.1 → XP_017448827.1  adhesion G protein-coupled receptor B2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A0N9, A0A8I6GF79
      Conserved Domains (5) summary
      smart00303
      Location:808 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:466 → 530
      HormR; Domain present in hormone receptors
      smart00209
      Location:304 → 352
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:867 → 1136
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:550 → 707
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    7. XM_017593340.1 → XP_017448829.1  adhesion G protein-coupled receptor B2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GF79
      Related
      ENSRNOP00000108277.1, ENSRNOT00000138640.1
      Conserved Domains (5) summary
      smart00303
      Location:808 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:466 → 530
      HormR; Domain present in hormone receptors
      smart00209
      Location:304 → 352
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:867 → 1103
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:550 → 707
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    8. XM_017593337.1 → XP_017448826.1  adhesion G protein-coupled receptor B2 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZJF8, A0A8I6GF79
      Related
      ENSRNOP00000077311.1, ENSRNOT00000100313.2
      Conserved Domains (5) summary
      smart00303
      Location:808 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:466 → 530
      HormR; Domain present in hormone receptors
      smart00209
      Location:302 → 352
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:867 → 1136
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:550 → 707
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    9. XM_017593339.1 → XP_017448828.1  adhesion G protein-coupled receptor B2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GF79
      Conserved Domains (5) summary
      smart00303
      Location:808 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:466 → 530
      HormR; Domain present in hormone receptors
      smart00209
      Location:302 → 352
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:867 → 1103
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:550 → 707
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    10. XM_039109800.1 → XP_038965728.1  adhesion G protein-coupled receptor B2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6GF79
      Conserved Domains (7) summary
      smart00303
      Location:808 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:466 → 530
      HormR; Domain present in hormone receptors
      smart00209
      Location:302 → 352
      TSP1; Thrombospondin type 1 repeats
      pfam16489
      Location:549 → 706
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      pfam19188
      Location:26 → 220
      AGRB_N; Adhesion GPCR B N-terminal region
      cd14964
      Location:869 → 894
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:867 → 1124
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    11. XM_039109801.1 → XP_038965729.1  adhesion G protein-coupled receptor B2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GF79
      Related
      ENSRNOP00000084957.2, ENSRNOT00000114531.2
      Conserved Domains (6) summary
      smart00303
      Location:753 → 806
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:411 → 475
      HormR; Domain present in hormone receptors
      smart00209
      Location:358 → 408
      TSP1; Thrombospondin type 1 repeats
      cd15988
      Location:812 → 1102
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:494 → 651
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      pfam19188
      Location:26 → 220
      AGRB_N; Adhesion GPCR B N-terminal region
    Nucleotide Protein Strain
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