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    Polk DNA polymerase kappa [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171525, updated on 9-Dec-2024

    Summary

    Official Symbol
    Polkprovided by RGD
    Official Full Name
    DNA polymerase kappaprovided by RGD
    Primary source
    RGD:620058
    See related
    EnsemblRapid:ENSRNOG00000060626 AllianceGenome:RGD:620058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dinb1
    Summary
    Predicted to enable DNA-directed DNA polymerase activity and molecular adaptor activity. Predicted to be involved in cellular response to UV; error-prone translesion synthesis; and nucleotide-excision repair, DNA gap filling. Predicted to act upstream of or within DNA repair. Predicted to be located in nuclear body and site of DNA damage. Predicted to be active in nucleus. Orthologous to human POLK (DNA polymerase kappa). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 54.9), Lung (RPKM 38.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Polk in Genome Data Viewer
    Location:
    2q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (29556831..29616960, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (27822228..27882331, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (27305718..27364906, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene POC5 centriolar protein Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene ceramide transporter 1 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA reductase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity  
    enables damaged DNA binding  
    enables metal ion binding  
    enables molecular adaptor activity  
    Process Evidence Code Pubs
    involved_in DNA damage response  
    acts_upstream_of_or_within DNA repair  
    involved_in DNA repair  
    involved_in biological_process  
    involved_in cellular response to UV  
    involved_in error-prone translesion synthesis  
    involved_in error-prone translesion synthesis  
    involved_in nucleotide-excision repair, DNA gap filling  
    Component Evidence Code Pubs
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in site of DNA damage  

    General protein information

    Preferred Names
    DNA polymerase kappa
    Names
    DNA-directed DNA polymerase kappa
    polymerase (DNA directed) kappa
    polymerase (DNA) kappa
    XP_038957600.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433859.1NP_001420788.1  DNA polymerase kappa

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K4L7, A6I508, B2RYH3
    2. NM_138516.2NP_612525.2  DNA polymerase kappa

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K4L7, A6I508, B2RYH3
      Related
      ENSRNOP00000073092.2, ENSRNOT00000078639.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      29556831..29616960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101672.2XP_038957600.1  DNA polymerase kappa isoform X1

      Conserved Domains (2) summary
      smart00734
      Location:760786
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:103513
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
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