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    Nmd3 NMD3 ribosome export adaptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310512, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nmd3provided by RGD
    Official Full Name
    NMD3 ribosome export adaptorprovided by RGD
    Primary source
    RGD:1308468
    See related
    EnsemblRapid:ENSRNOG00000009310 AllianceGenome:RGD:1308468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308468
    Summary
    Predicted to enable protein-macromolecule adaptor activity and ribosomal large subunit binding activity. Predicted to be involved in positive regulation of RNA biosynthetic process; positive regulation of protein localization to nucleolus; and ribosomal large subunit export from nucleus. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human NMD3 (NMD3 ribosome export adaptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 232.8), Thymus (RPKM 159.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nmd3 in Genome Data Viewer
    Location:
    2q32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (156285773..156348394)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (154012973..154038466)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (166402838..166428331)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphoserine aminotransferase 1, pseudogene 1 Neighboring gene RB binding protein 4, chromatin remodeling factor like 1 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 13 Neighboring gene serine palmitoyltransferase, small subunit B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maturation of eukaryotic ribosomes: acquisition of functionality. Panse VG, et al. Trends Biochem Sci, 2010 May. PMID 20137954, Free PMC Article
    2. Nuclear export and cytoplasmic maturation of ribosomal subunits. Zemp I, et al. FEBS Lett, 2007 Jun 19. PMID 17509569
    3. Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. Thomas F, et al. J Cell Sci, 2003 Jun 15. PMID 12724356
    4. CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis. Bai B, et al. Nucleus, 2013 Jul-Aug. PMID 23782956, Free PMC Article
    5. Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates. Trotta CR, et al. EMBO J, 2003 Jun 2. PMID 12773398, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal large subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of RNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    60S ribosomal export protein NMD3
    Names
    NMD3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107682.2 → NP_001101152.1  60S ribosomal export protein NMD3

      See identical proteins and their annotated locations for NP_001101152.1

      Status: VALIDATED

      Source sequence(s)
      BC161998
      UniProtKB/TrEMBL
      A0A9K3Y797, A6J5N6, B1WC44, F7ERL4
      Related
      ENSRNOP00000012417.8, ENSRNOT00000012417.9
      Conserved Domains (1) summary
      pfam04981
      Location:17 → 246
      NMD3; NMD3 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      156285773..156348394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281803.1 → XP_063137873.1  60S ribosomal export protein NMD3 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y797, A6J5N6, B1WC44, F7ERL4

    2. XM_063281802.1 → XP_063137872.1  60S ribosomal export protein NMD3 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y797, A6J5N6, B1WC44, F7ERL4

    3. XM_039102292.2 → XP_038958220.1  60S ribosomal export protein NMD3 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y797, A6J5N6, B1WC44, F7ERL4
      Conserved Domains (1) summary
      pfam04981
      Location:17 → 246
      NMD3; NMD3 family

    4. XM_039102293.2 → XP_038958221.1  60S ribosomal export protein NMD3 isoform X3

      Conserved Domains (1) summary
      pfam04981
      Location:1 → 126
      NMD3; NMD3 family

    5. XM_063281804.1 → XP_063137874.1  60S ribosomal export protein NMD3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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