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    Wnt2 Wnt family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114487, updated on 4-Jan-2025

    Summary

    Official Symbol
    Wnt2provided by RGD
    Official Full Name
    Wnt family member 2provided by RGD
    Primary source
    RGD:621346
    See related
    EnsemblRapid:ENSRNOG00000089988 AllianceGenome:RGD:621346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wnt
    Summary
    Predicted to enable cytokine activity and frizzled binding activity. Involved in lung development and positive regulation of endothelial cell proliferation. Predicted to be located in collagen-containing extracellular matrix; cytoplasm; and extracellular region. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Uterus (RPKM 59.5), Lung (RPKM 52.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Wnt2 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (47294300..47340284, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (46328408..46374673, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (45286845..45332899, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene suppression of tumorigenicity 7 Neighboring gene 60S ribosomal protein L23a-like Neighboring gene uncharacterized LOC134486733 Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1 Neighboring gene CF transmembrane conductance regulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity  
    enables frizzled binding  
    enables receptor ligand activity  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway  
    acts_upstream_of_or_within atrial cardiac muscle tissue morphogenesis  
    acts_upstream_of_or_within canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    acts_upstream_of_or_within cardiac epithelial to mesenchymal transition  
    acts_upstream_of cardiac muscle cell proliferation  
    involved_in cell proliferation in midbrain  
    involved_in cell-cell signaling  
    involved_in cellular response to transforming growth factor beta stimulus  
    acts_upstream_of epithelial cell proliferation  
    acts_upstream_of epithelial cell proliferation involved in lung morphogenesis  
    acts_upstream_of_or_within labyrinthine layer blood vessel development  
    involved_in lung development PubMed 
    acts_upstream_of_or_within lung induction  
    involved_in mammary gland epithelium development  
    acts_upstream_of mesenchymal cell proliferation  
    involved_in midbrain dopaminergic neuron differentiation  
    involved_in positive regulation of DNA-binding transcription factor activity  
    acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of endothelial cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis  
    involved_in positive regulation of fibroblast proliferation  
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation  
    involved_in positive regulation of neurogenesis  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix  
    located_in cytoplasm  
    located_in extracellular region  

    General protein information

    Preferred Names
    protein Wnt-2
    Names
    wingless-related MMTV integration site 2
    wingless-type MMTV integration site 2
    wingless-type MMTV integration site family member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053695.1 → NP_446147.1  protein Wnt-2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JZF4, A6IE38, Q2IBD1
      Related
      ENSRNOP00000104014.1, ENSRNOT00000169749.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      47294300..47340284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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