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    Cd93 CD93 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd93provided by RGD
    Official Full Name
    CD93 moleculeprovided by RGD
    Primary source
    RGD:621251
    See related
    EnsemblRapid:ENSRNOG00000024799 AllianceGenome:RGD:621251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ly68; C1qRp; C1qr1
    Summary
    Predicted to enable complement component C1q complex binding activity and signaling receptor activity. Predicted to be involved in angiogenesis and cell-cell adhesion. Predicted to be located in cell surface; cytoplasmic vesicle; and plasma membrane. Orthologous to human CD93 (CD93 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 632.7), Heart (RPKM 284.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd93 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (156345019..156351537, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (135891859..135898378, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (142778798..142783774, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene somatostatin receptor 4 Neighboring gene thrombomodulin Neighboring gene uncharacterized LOC103691916 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin. Dean YD, et al. J Biol Chem, 2000 Nov 3. PMID 10934210
    2. Synergistic regulation of microglia differentiation by CD93 and integrin β1 in the rat pneumococcal meningitis model. Qiao N, et al. Immunol Lett, 2022 Dec. PMID 36336138
    3. Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation. Qiao N, et al. Ann Clin Lab Sci, 2022 Jul. PMID 36197773
    4. Identification of a receptor for neuropeptide VGF and its role in neuropathic pain. Chen YC, et al. J Biol Chem, 2013 Nov 29. PMID 24106277, Free PMC Article
    5. Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR. Bellot G, et al. J Mol Biol, 2009 May 8. PMID 19285506

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synergistic regulation of microglia differentiation by CD93 and integrin beta1 in the rat pneumococcal meningitis model.
      Title: Synergistic regulation of microglia differentiation by CD93 and integrin β1 in the rat pneumococcal meningitis model.
    2. Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation.
      Title: Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation.
    3. These results indicate that gC1qR is the receptor for TLQP-21 and plays an important role in chronic pain through activation of macrophages
      Title: Identification of a receptor for neuropeptide VGF and its role in neuropathic pain.
    4. The authors observed that binding of gC1qR to the full-length receptor modifies the intrinsic tryptophan fluorescence binding curves of V2 to an antagonist.
      Title: Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables complement component C1q complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement component C1q receptor
    Names
    C1q/MBL/SPA receptor
    C1qR(p)
    CD93 antigen
    cell surface antigen AA4
    complement component 1 q subcomponent receptor 1
    lymphocyte antigen 68

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053383.4 → NP_445835.2  complement component C1q receptor precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q9ET61, Q9JIZ6
      UniProtKB/TrEMBL
      A6K7C0
      Related
      ENSRNOP00000089608.1, ENSRNOT00000076493.3
      Conserved Domains (5) summary
      smart00179
      Location:424 → 462
      EGF_CA; Calcium-binding EGF-like domain
      pfam00008
      Location:303 → 331
      EGF; EGF-like domain
      pfam12662
      Location:323 → 345
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:261 → 297
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl02432
      Location:30 → 183
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      156345019..156351537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ET61.1 GenPept UniProtKB/Swiss-Prot:Q9ET61

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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