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    Vamp8 vesicle-associated membrane protein 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83730, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vamp8provided by RGD
    Official Full Name
    vesicle-associated membrane protein 8provided by RGD
    Primary source
    RGD:620421
    See related
    EnsemblRapid:ENSRNOG00000012748 AllianceGenome:RGD:620421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables SNAP receptor activity and syntaxin binding activity. Involved in protein-containing complex assembly and vesicle fusion. Located in endosome; lysosomal membrane; and midbody. Part of SNARE complex. Orthologous to human VAMP8 (vesicle associated membrane protein 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 1046.1), Kidney (RPKM 774.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Vamp8 in Genome Data Viewer
    Location:
    4q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (106000570..106011081, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104442383..104452884, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (100250301..100252756, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 150A Neighboring gene ring finger protein 181 Neighboring gene vesicle-associated membrane protein 5 Neighboring gene uncharacterized LOC134486592 Neighboring gene uncharacterized LOC134486591 Neighboring gene gamma-glutamyl carboxylase Neighboring gene methionine adenosyltransferase 2A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNAP receptor activity  
    enables SNAP receptor activity PubMed 
    enables chloride channel inhibitor activity  
    enables chloride channel inhibitor activity  
    enables protein binding PubMed 
    enables syntaxin binding  
    enables syntaxin binding PubMed 
    Items 1 - 25 of 34
    Process Evidence Code Pubs
    involved_in SNARE complex assembly  
    involved_in SNARE complex assembly  
    involved_in autophagosome maturation  
    involved_in autophagosome maturation  
    involved_in autophagosome membrane docking  
    involved_in autophagosome membrane docking  
    involved_in autophagy  
    acts_upstream_of_or_within cellular response to type II interferon  
    involved_in defense response to virus  
    NOT involved_in eosinophil degranulation  
    acts_upstream_of_or_within establishment of localization in cell  
    involved_in membrane fusion PubMed 
    involved_in mucus secretion  
    involved_in mucus secretion  
    involved_in mucus secretion  
    involved_in negative regulation of secretion by cell  
    involved_in negative regulation of secretion by cell  
    NOT involved_in neutrophil degranulation  
    involved_in positive regulation of histamine secretion by mast cell  
    involved_in positive regulation of histamine secretion by mast cell  
    acts_upstream_of_or_within positive regulation of pancreatic amylase secretion  
    involved_in protein transport  
    involved_in protein-containing complex assembly PubMed 
    acts_upstream_of_or_within regulation of endocytosis  
    involved_in regulation of protein localization to plasma membrane  
    involved_in regulation of protein localization to plasma membrane  
    involved_in symbiont entry into host cell  
    acts_upstream_of_or_within symbiont entry into host cell  
    involved_in vesicle fusion  
    involved_in vesicle fusion PubMed 
    acts_upstream_of_or_within vesicle fusion  
    involved_in vesicle-mediated transport PubMed 
    involved_in vesicle-mediated transport  
    acts_upstream_of_or_within zymogen granule exocytosis  
    Items 1 - 25 of 34
    Items 1 - 20 of 40
    Component Evidence Code Pubs
    part_of SNARE complex  
    part_of SNARE complex PubMed 
    part_of SNARE complex  
    part_of SNARE complex  
    located_in azurophil granule membrane  
    located_in azurophil granule membrane  
    located_in basal part of cell  
    located_in basolateral part of cell  
    located_in basolateral plasma membrane  
    located_in cell surface  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in early endosome membrane  
    located_in late endosome membrane PubMed 
    located_in late endosome membrane  
    located_in late endosome membrane  
    located_in lysosomal membrane PubMed 
    located_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in lysosome  
    located_in membrane  
    located_in midbody PubMed 
    is_active_in mucin granule  
    located_in mucin granule  
    located_in mucin granule  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in phagocytic vesicle  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in recycling endosome PubMed 
    located_in recycling endosome  
    located_in recycling endosome  
    located_in secretory granule  
    located_in secretory granule membrane  
    located_in vesicle  
    located_in zymogen granule  
    located_in zymogen granule membrane  
    Items 1 - 20 of 40

    General protein information

    Preferred Names
    vesicle-associated membrane protein 8
    Names
    EDB
    VAMP-8
    endobrevin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031827.2NP_114015.1  vesicle-associated membrane protein 8

      See identical proteins and their annotated locations for NP_114015.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q9WUF4
      UniProtKB/TrEMBL
      A0A8I6AB54, A6IAB7
      Related
      ENSRNOP00000083978.1, ENSRNOT00000096938.2
      Conserved Domains (2) summary
      cd15868
      Location:975
      R-SNARE_VAMP8; SNARE motif of VAMP8
      pfam00957
      Location:875
      Synaptobrevin; Synaptobrevin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      106000570..106011081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108449.2XP_038964377.1  vesicle-associated membrane protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AB54, F1LNT8
      Related
      ENSRNOP00000017301.3, ENSRNOT00000017301.6
      Conserved Domains (1) summary
      cd15868
      Location:2591
      R-SNARE_VAMP8; SNARE motif of VAMP8
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