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    Scn3b sodium voltage-gated channel beta subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245956, updated on 9-Dec-2024

    Summary

    Official Symbol
    Scn3bprovided by RGD
    Official Full Name
    sodium voltage-gated channel beta subunit 3provided by RGD
    Primary source
    RGD:621657
    See related
    EnsemblRapid:ENSRNOG00000057221 AllianceGenome:RGD:621657
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Scnb3
    Summary
    Predicted to enable sodium channel inhibitor activity; transmembrane transporter binding activity; and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in nervous system development and sodium ion transport. Predicted to be located in Z disc and plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 199.0), Lung (RPKM 195.3) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Scn3b in Genome Data Viewer
    Location:
    8q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (49527529..49550019)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (40630372..40652869)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (44136413..44159011)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094120 Neighboring gene zinc finger protein 202 Neighboring gene olfactory receptor family 6 subfamily X member 1 Neighboring gene GRAM domain containing 1B Neighboring gene uncharacterized LOC134480034 Neighboring gene uncharacterized LOC134480035

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in SA node cell action potential  
    involved_in atrial cardiac muscle cell action potential  
    acts_upstream_of_or_within cardiac conduction  
    involved_in cardiac muscle cell action potential involved in contraction  
    involved_in cardiac muscle contraction  
    involved_in membrane depolarization  
    involved_in membrane depolarization during action potential  
    involved_in membrane depolarization during cardiac muscle cell action potential  
    involved_in membrane depolarization during cardiac muscle cell action potential  
    involved_in nervous system development PubMed 
    involved_in positive regulation of heart rate  
    involved_in positive regulation of sodium ion transport  
    involved_in protein localization to plasma membrane  
    involved_in regulation of atrial cardiac muscle cell membrane depolarization  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of ventricular cardiac muscle cell membrane depolarization  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transport PubMed 
    involved_in ventricular cardiac muscle cell action potential  
    acts_upstream_of_or_within ventricular cardiac muscle cell action potential  
    involved_in ventricular cardiac muscle cell action potential  
    Component Evidence Code Pubs
    located_in Z disc  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of voltage-gated sodium channel complex  
    part_of voltage-gated sodium channel complex  

    General protein information

    Preferred Names
    sodium channel regulatory subunit beta-3; sodium channel subunit beta-3
    Names
    sodium channel beta 3 subunit
    sodium channel, voltage-gated, type III, beta subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139097.3NP_620797.1  sodium channel regulatory subunit beta-3 precursor

      See identical proteins and their annotated locations for NP_620797.1

      Status: PROVISIONAL

      Source sequence(s)
      BC070899
      UniProtKB/Swiss-Prot
      Q9JK00
      UniProtKB/TrEMBL
      A6J3Q2
      Related
      ENSRNOP00000071448.1, ENSRNOT00000087022.3
      Conserved Domains (2) summary
      pfam07686
      Location:28122
      V-set; Immunoglobulin V-set domain
      cd00096
      Location:3137
      Ig; Ig strand A' [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      49527529..49550019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264913.1XP_063120983.1  sodium channel subunit beta-3 isoform X1

      UniProtKB/Swiss-Prot
      Q9JK00
      UniProtKB/TrEMBL
      A6J3Q2
    2. XM_063264914.1XP_063120984.1  sodium channel subunit beta-3 isoform X1

      UniProtKB/Swiss-Prot
      Q9JK00
      UniProtKB/TrEMBL
      A6J3Q2
    3. XM_039080819.2XP_038936747.1  sodium channel subunit beta-3 isoform X2

      Conserved Domains (2) summary
      pfam07686
      Location:282
      V-set; Immunoglobulin V-set domain
      cd00096
      Location:3338
      Ig; Ig strand C' [structural motif]
    4. XM_017595466.2XP_017450955.1  sodium channel subunit beta-3 isoform X2

      Related
      ENSRNOP00000109471.1, ENSRNOT00000158727.1
      Conserved Domains (2) summary
      pfam07686
      Location:282
      V-set; Immunoglobulin V-set domain
      cd00096
      Location:3338
      Ig; Ig strand C' [structural motif]
    5. XM_006243102.3XP_006243164.1  sodium channel subunit beta-3 isoform X1

      See identical proteins and their annotated locations for XP_006243164.1

      UniProtKB/Swiss-Prot
      Q9JK00
      UniProtKB/TrEMBL
      A6J3Q2
      Conserved Domains (2) summary
      pfam07686
      Location:28122
      V-set; Immunoglobulin V-set domain
      cd00096
      Location:3137
      Ig; Ig strand A' [structural motif]
    6. XM_006243103.3XP_006243165.1  sodium channel subunit beta-3 isoform X1

      See identical proteins and their annotated locations for XP_006243165.1

      UniProtKB/Swiss-Prot
      Q9JK00
      UniProtKB/TrEMBL
      A6J3Q2
      Conserved Domains (2) summary
      pfam07686
      Location:28122
      V-set; Immunoglobulin V-set domain
      cd00096
      Location:3137
      Ig; Ig strand A' [structural motif]
    7. XM_063264915.1XP_063120985.1  sodium channel subunit beta-3 isoform X2

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