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    Cox6b1 cytochrome c oxidase subunit 6B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688869, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cox6b1provided by RGD
    Official Full Name
    cytochrome c oxidase subunit 6B1provided by RGD
    Primary source
    RGD:1584097
    See related
    EnsemblRapid:ENSRNOG00000024309 AllianceGenome:RGD:1584097
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cox6b
    Summary
    Predicted to be involved in substantia nigra development. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Orthologous to human COX6B1 (cytochrome c oxidase subunit 6B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 5203.7), Muscle (RPKM 3130.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Cox6b1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95002513..95011516, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85875080..85884081, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89075987..89084834, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 32 Neighboring gene uroplakin 1A Neighboring gene ETS variant transcription factor 2 Neighboring gene RNA binding motif protein 42

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial membrane  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion  
    part_of respiratory chain complex IV  
    part_of respiratory chain complex IV  

    General protein information

    Preferred Names
    cytochrome c oxidase subunit 6B1
    Names
    COX VIb-1
    cytochrome c oxidase subunit VIb
    cytochrome c oxidase, subunit VIb polypeptide 1
    NP_001138745.1
    XP_006228857.1
    XP_038947145.1
    XP_063130482.1
    XP_063130488.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145273.1NP_001138745.1  cytochrome c oxidase subunit 6B1

      See identical proteins and their annotated locations for NP_001138745.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A8X0, A6JA04
      Conserved Domains (1) summary
      cd00926
      Location:885
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95002513..95011516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228795.3XP_006228857.1  cytochrome c oxidase subunit 6B1 isoform X1

      See identical proteins and their annotated locations for XP_006228857.1

      UniProtKB/TrEMBL
      A0A8I6A8X0, A6JA04
      Conserved Domains (1) summary
      cd00926
      Location:885
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    2. XM_039091217.2XP_038947145.1  cytochrome c oxidase subunit 6B1 isoform X2

      UniProtKB/TrEMBL
      A6JA04, D3ZSB0
      Related
      ENSRNOP00000030997.3, ENSRNOT00000032026.5
      Conserved Domains (1) summary
      cd00926
      Location:870
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    3. XM_063274412.1XP_063130482.1  cytochrome c oxidase subunit 6B1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8X0, A6JA04
    4. XM_063274418.1XP_063130488.1  cytochrome c oxidase subunit 6B1 isoform X2

      UniProtKB/TrEMBL
      A6JA04, D3ZSB0
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