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    Fbln1 fibulin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315191, updated on 9-Dec-2024

    Summary

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    Symbol
    Fbln1provided by RGD
    Full Name
    fibulin 1provided by RGD
    Primary source
    RGD:1308667
    See related
    EnsemblRapid:ENSRNOG00000014137 AllianceGenome:RGD:1308667
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including fibrinogen binding activity; fibronectin binding activity; and integrin binding activity. Predicted to be an extracellular matrix structural constituent. Involved in embryo implantation. Predicted to be located in basement membrane; elastic fiber; and extracellular space. Orthologous to human FBLN1 (fibulin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 359.0), Lung (RPKM 275.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbln1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (118190347..118269965)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (116310582..116390075)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (126096793..126176468)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene RIB43A domain with coiled-coils 2 Neighboring gene uncharacterized LOC134479609 Neighboring gene uncharacterized LOC120093703 Neighboring gene uncharacterized LOC120093704 Neighboring gene U2 spliceosomal RNA Neighboring gene ataxin 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cycle-dependent endometrial expression and hormonal regulation of the fibulin-1 gene. Haendler B, et al. Mol Reprod Dev, 2004 Jul. PMID 15112320
    2. Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure. Argraves WS, et al. J Cell Biol, 1990 Dec. PMID 2269669, Free PMC Article
    3. Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin. Balbona K, et al. J Biol Chem, 1992 Oct 5. PMID 1400330
    4. Interaction of oncogenic papillomavirus E6 proteins with fibulin-1. Du M, et al. Biochem Biophys Res Commun, 2002 Aug 30. PMID 12200142
    5. Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion. Simkhovich BZ, et al. Arch Biochem Biophys, 2003 Dec 15. PMID 14654066

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus.
      Title: Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus.
    2. fibulin-1 and -2 respond differentially to single and repeated damaging noxae, and their expression is differently present in liver cells
      Title: Expression of ECM proteins fibulin-1 and -2 in acute and chronic liver disease and in cultured rat liver cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables extracellular matrix structural constituent ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fibrinogen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation, fibrin clot formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryo implantation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in elastic fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fibulin-1
    Names
    Fbln1 protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127547.1 → NP_001121019.1  fibulin-1 precursor

      See identical proteins and their annotated locations for NP_001121019.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A0A0G2JY81, A6HTD8
      Related
      ENSRNOP00000046622.5, ENSRNOT00000047234.6
      Conserved Domains (5) summary
      smart00179
      Location:358 → 391
      EGF_CA; Calcium-binding EGF-like domain
      cd00017
      Location:107 → 162
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam07645
      Location:218 → 261
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:423 → 446
      cEGF; Complement Clr-like EGF-like
      cl00057
      Location:481 → 524
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      118190347..118269965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242161.4 → XP_006242223.1  fibulin-1 isoform X1

      See identical proteins and their annotated locations for XP_006242223.1

      UniProtKB/TrEMBL
      B1WC21, D3ZQ25
      Related
      ENSRNOP00000109223.1, ENSRNOT00000136577.1
      Conserved Domains (5) summary
      smart00179
      Location:358 → 391
      EGF_CA; Calcium-binding EGF-like domain
      cd00017
      Location:107 → 162
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam07645
      Location:218 → 261
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:423 → 446
      cEGF; Complement Clr-like EGF-like
      cl00057
      Location:481 → 524
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein Strain
    Heading Accession and Version

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