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    Get1 guided entry of tail-anchored proteins factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288233, updated on 9-Dec-2024

    Summary

    Official Symbol
    Get1provided by RGD
    Official Full Name
    guided entry of tail-anchored proteins factor 1provided by RGD
    Primary source
    RGD:735104
    See related
    EnsemblRapid:ENSRNOG00000001629 AllianceGenome:RGD:735104
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wrb
    Summary
    Predicted to enable protein-membrane adaptor activity. Involved in tail-anchored membrane protein insertion into ER membrane. Part of GET complex. Orthologous to human GET1 (guided entry of tail-anchored proteins factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 175.2), Heart (RPKM 142.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Get1 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (48915298..48929235)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (35438555..35460156)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (36497513..36511445)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL43-like Neighboring gene high mobility group nucleosome binding domain 1 Neighboring gene lebercilin LCA5 like Neighboring gene SH3 domain binding glutamate-rich protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of GET complex  
    part_of GET complex PubMed 
    part_of GET complex  
    located_in endoplasmic reticulum membrane  

    General protein information

    Preferred Names
    guided entry of tail-anchored proteins factor 1
    Names
    tail-anchored protein insertion receptor WRB
    tryptophan rich basic protein
    tryptophan-rich protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199373.1NP_955405.1  guided entry of tail-anchored proteins factor 1

      See identical proteins and their annotated locations for NP_955405.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062049
      UniProtKB/Swiss-Prot
      Q6P6S5
      UniProtKB/TrEMBL
      A6KPR9, A6KPS0
      Related
      ENSRNOP00000002222.3, ENSRNOT00000002222.7
      Conserved Domains (1) summary
      pfam04420
      Location:17163
      CHD5; CHD5-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      48915298..48929235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088205.2XP_038944133.1  guided entry of tail-anchored proteins factor 1 isoform X1

      UniProtKB/TrEMBL
      A6KPS1
      Conserved Domains (1) summary
      pfam04420
      Location:1115
      CHD5; CHD5-like protein
    2. XM_039088204.2XP_038944132.1  guided entry of tail-anchored proteins factor 1 isoform X1

      UniProtKB/TrEMBL
      A6KPS1
      Conserved Domains (1) summary
      pfam04420
      Location:1115
      CHD5; CHD5-like protein
    3. XM_039088208.2XP_038944136.1  guided entry of tail-anchored proteins factor 1 isoform X1

      UniProtKB/TrEMBL
      A6KPS1
      Conserved Domains (1) summary
      pfam04420
      Location:1115
      CHD5; CHD5-like protein
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