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    Zfp207 zinc finger protein 207 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303763, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Zfp207provided by RGD
    Official Full Name
    zinc finger protein 207provided by RGD
    Primary source
    RGD:1308121
    See related
    EnsemblRapid:ENSRNOG00000000236 AllianceGenome:RGD:1308121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heparin binding activity and microtubule binding activity. Predicted to be involved in mitotic spindle assembly checkpoint signaling; nuclear chromosome segregation; and protein stabilization. Predicted to be located in kinetochore; nuclear lumen; and spindle matrix. Orthologous to human ZNF207 (zinc finger protein 207). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 351.4), Spleen (RPKM 239.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp207 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65883630..65895895)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65385807..65398086)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67762970..67784854)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene rhomboid like 3 Neighboring gene similar to human chromosome 17 open reading frame 75 Neighboring gene microRNA 632 Neighboring gene proteasome 26S subunit, non-ATPase 11 Neighboring gene cyclin-dependent kinase 5 regulatory subunit 1 like Neighboring gene cyclin-dependent kinase 5 regulatory subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Zep: A novel zinc finger protein containing a large proline-rich domain. Taguchi E, et al. J Biochem, 1998 Dec 1. PMID 9832628
    2. Phase transition of spindle-associated protein regulate spindle apparatus assembly. Jiang H, et al. Cell, 2015 Sep 24. PMID 26388440, Free PMC Article
    3. BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment. Toledo CM, et al. Dev Cell, 2014 Feb 10. PMID 24462187, Free PMC Article
    4. A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting. Jiang H, et al. Dev Cell, 2014 Feb 10. PMID 24462186, Free PMC Article
    5. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Misawa K, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10716735, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116398

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle matrix ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BUB3-interacting and GLEBS motif-containing protein ZNF207

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039020.3 → NP_001034109.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 1

      See identical proteins and their annotated locations for NP_001034109.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      Q498C9
      Related
      ENSRNOP00000104924.1, ENSRNOT00000156436.1
      Conserved Domains (3) summary
      sd00020
      Location:13 → 34
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:406 → 441
      SMN; Survival motor neuron protein (SMN)
      cd20908
      Location:10 → 90
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    2. NM_001393767.2 → NP_001380696.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHB3
      Related
      ENSRNOP00000106957.1, ENSRNOT00000147517.1
      Conserved Domains (3) summary
      sd00020
      Location:13 → 34
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:437 → 472
      SMN; Survival motor neuron protein (SMN)
      cd20908
      Location:10 → 90
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      65883630..65895895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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