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    Akt1 AKT serine/threonine kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24185, updated on 9-Dec-2024

    Summary

    Official Symbol
    Akt1provided by RGD
    Official Full Name
    AKT serine/threonine kinase 1provided by RGD
    Primary source
    RGD:2081
    See related
    EnsemblRapid:ENSRNOG00000028629 AllianceGenome:RGD:2081
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akt
    Summary
    Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and enzyme binding activity. Involved in several processes, including cellular response to mechanical stimulus; glycogen biosynthetic process; and regulation of protein metabolic process. Acts upstream of or within several processes, including negative regulation of cell size; positive regulation of sodium ion transport; and regulation of protein localization. Located in dendrite and nucleus. Used to study autosomal recessive polycystic kidney disease; hypertension; impotence; myocardial infarction; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; gastrointestinal system cancer (multiple); opiate dependence; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); colorectal cancer (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 317.3), Adrenal (RPKM 243.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Akt1 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137534810..137555131, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131713716..131735319, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137218398..137239970, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene adenylosuccinate synthase 1 Neighboring gene SIVA1, apoptosis-inducing factor Neighboring gene zinc finger and BTB domain containing 42 Neighboring gene uncharacterized LOC134479262

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 63
    Function Evidence Code Pubs
    enables 14-3-3 protein binding  
    enables 14-3-3 protein binding  
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables ATP binding  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables GTPase activating protein binding PubMed 
    enables Rho-dependent protein serine/threonine kinase activity  
    enables calmodulin binding  
    enables calmodulin binding  
    enables calmodulin binding  
    enables enzyme binding PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding  
    enables kinase activity  
    enables nitric-oxide synthase regulator activity  
    enables nitric-oxide synthase regulator activity  
    enables phosphatidylinositol-3,4,5-trisphosphate binding  
    enables phosphatidylinositol-3,4,5-trisphosphate binding  
    enables phosphatidylinositol-3,4-bisphosphate binding  
    enables phosphatidylinositol-3,4-bisphosphate binding  
    enables potassium channel activator activity  
    enables potassium channel activator activity  
    enables potassium channel activator activity  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase C binding PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein kinase binding  
    enables protein kinase binding PubMed 
    enables protein kinase binding  
    enables protein phosphatase 2A binding PubMed 
    enables protein serine kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase binding PubMed 
    enables protein serine/threonine kinase inhibitor activity PubMed 
    enables protein serine/threonine/tyrosine kinase activity  
    enables protein serine/threonine/tyrosine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 63
    Items 1 - 25 of 258
    Process Evidence Code Pubs
    involved_in DNA damage response PubMed 
    involved_in activation-induced cell death of T cells  
    acts_upstream_of_or_within activation-induced cell death of T cells  
    involved_in apoptotic mitochondrial changes  
    acts_upstream_of_or_within apoptotic mitochondrial changes  
    involved_in behavioral response to pain  
    involved_in behavioral response to pain  
    involved_in cell migration involved in sprouting angiogenesis  
    involved_in cell migration involved in sprouting angiogenesis  
    acts_upstream_of_or_within cell projection organization PubMed 
    involved_in cellular response to decreased oxygen levels  
    acts_upstream_of_or_within cellular response to decreased oxygen levels  
    involved_in cellular response to epidermal growth factor stimulus PubMed 
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus  
    acts_upstream_of_or_within cellular response to granulocyte macrophage colony-stimulating factor stimulus  
    acts_upstream_of_or_within cellular response to growth factor stimulus  
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to insulin stimulus PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus PubMed 
    involved_in cellular response to insulin stimulus PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus  
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in cellular response to nerve growth factor stimulus PubMed 
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to nerve growth factor stimulus PubMed 
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to organic cyclic compound PubMed 
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus  
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus  
    involved_in cellular response to peptide  
    involved_in cellular response to peptide PubMed 
    acts_upstream_of_or_within cellular response to peptide  
    involved_in cellular response to platelet-derived growth factor stimulus PubMed 
    involved_in cellular response to prostaglandin E stimulus  
    acts_upstream_of_or_within cellular response to prostaglandin E stimulus  
    involved_in cellular response to tumor necrosis factor  
    acts_upstream_of_or_within cellular response to tumor necrosis factor  
    involved_in cellular response to vascular endothelial growth factor stimulus  
    acts_upstream_of_or_within cellular response to vascular endothelial growth factor stimulus  
    involved_in chromatin remodeling  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in establishment of protein localization to mitochondrion  
    involved_in establishment of protein localization to mitochondrion  
    involved_in execution phase of apoptosis  
    acts_upstream_of_or_within execution phase of apoptosis  
    involved_in gene expression  
    acts_upstream_of_or_within_positive_effect gene expression  
    acts_upstream_of_or_within germ cell development  
    involved_in glucose homeostasis  
    acts_upstream_of_or_within glucose homeostasis  
    involved_in glucose metabolic process  
    acts_upstream_of_or_within glucose metabolic process  
    involved_in glycogen biosynthetic process  
    involved_in glycogen biosynthetic process PubMed 
    involved_in glycogen cell differentiation involved in embryonic placenta development  
    acts_upstream_of_or_within glycogen cell differentiation involved in embryonic placenta development  
    involved_in glycogen metabolic process  
    acts_upstream_of_or_within glycogen metabolic process  
    involved_in inflammatory response  
    acts_upstream_of_or_within inflammatory response  
    involved_in inflammatory response  
    involved_in insulin receptor signaling pathway PubMed 
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway PubMed 
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in interleukin-18-mediated signaling pathway  
    involved_in interleukin-18-mediated signaling pathway  
    involved_in intracellular signal transduction  
    acts_upstream_of_or_within intracellular signal transduction  
    involved_in labyrinthine layer blood vessel development  
    acts_upstream_of_or_within labyrinthine layer blood vessel development  
    involved_in lipopolysaccharide-mediated signaling pathway  
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway  
    involved_in maintenance of protein location in mitochondrion  
    involved_in maintenance of protein location in mitochondrion  
    involved_in mammalian oogenesis stage  
    acts_upstream_of_or_within mammalian oogenesis stage  
    involved_in maternal placenta development  
    acts_upstream_of_or_within maternal placenta development  
    involved_in negative regulation of JNK cascade PubMed 
    involved_in negative regulation of PERK-mediated unfolded protein response  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of autophagy  
    involved_in negative regulation of autophagy  
    involved_in negative regulation of cGAS/STING signaling pathway  
    involved_in negative regulation of cGAS/STING signaling pathway  
    involved_in negative regulation of calcium import into the mitochondrion PubMed 
    acts_upstream_of_or_within negative regulation of cell size PubMed 
    involved_in negative regulation of cilium assembly  
    involved_in negative regulation of cilium assembly  
    involved_in negative regulation of cilium assembly  
    involved_in negative regulation of cysteine-type endopeptidase activity  
    involved_in negative regulation of endopeptidase activity  
    involved_in negative regulation of fatty acid beta-oxidation  
    involved_in negative regulation of fatty acid beta-oxidation  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    involved_in negative regulation of leukocyte cell-cell adhesion  
    involved_in negative regulation of leukocyte cell-cell adhesion  
    involved_in negative regulation of long-chain fatty acid import across plasma membrane  
    involved_in negative regulation of long-chain fatty acid import across plasma membrane  
    involved_in negative regulation of lymphocyte migration  
    involved_in negative regulation of lymphocyte migration  
    involved_in negative regulation of protein kinase activity PubMed 
    involved_in negative regulation of protein kinase activity  
    involved_in negative regulation of protein localization to lysosome  
    involved_in negative regulation of protein localization to lysosome  
    involved_in negative regulation of protein localization to lysosome  
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of proteolysis  
    involved_in negative regulation of proteolysis  
    involved_in negative regulation of release of cytochrome c from mitochondria  
    involved_in negative regulation of release of cytochrome c from mitochondria  
    involved_in negative regulation of release of cytochrome c from mitochondria  
    involved_in negative regulation of superoxide anion generation PubMed 
    involved_in osteoblast differentiation  
    acts_upstream_of_or_within osteoblast differentiation  
    involved_in osteoblast differentiation  
    involved_in peptidyl-serine phosphorylation PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-threonine phosphorylation  
    involved_in peripheral nervous system myelin maintenance  
    acts_upstream_of_or_within peripheral nervous system myelin maintenance  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphorylation  
    involved_in phosphorylation  
    involved_in positive regulation of D-glucose import  
    involved_in positive regulation of D-glucose import  
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of TORC1 signaling  
    involved_in positive regulation of TORC1 signaling  
    involved_in positive regulation of TORC1 signaling  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in positive regulation of endodeoxyribonuclease activity  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of fat cell differentiation  
    involved_in positive regulation of fat cell differentiation  
    involved_in positive regulation of fibroblast migration  
    acts_upstream_of_or_within positive regulation of fibroblast migration  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of glucose metabolic process  
    involved_in positive regulation of glycogen biosynthetic process  
    involved_in positive regulation of glycogen biosynthetic process  
    involved_in positive regulation of lipid biosynthetic process  
    involved_in positive regulation of lipid biosynthetic process  
    involved_in positive regulation of lipid biosynthetic process  
    involved_in positive regulation of mitochondrial membrane potential PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of nitric-oxide synthase activity  
    involved_in positive regulation of organ growth  
    acts_upstream_of_or_within positive regulation of organ growth  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of protein localization to cell surface  
    involved_in positive regulation of protein localization to cell surface  
    involved_in positive regulation of protein localization to endoplasmic reticulum  
    involved_in positive regulation of protein localization to endoplasmic reticulum  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein metabolic process PubMed 
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of sodium ion transport  
    acts_upstream_of_or_within positive regulation of sodium ion transport PubMed 
    acts_upstream_of_or_within positive regulation of sodium ion transport  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of vasoconstriction PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in protein autophosphorylation PubMed 
    acts_upstream_of_or_within protein catabolic process  
    involved_in protein import into nucleus  
    involved_in protein import into nucleus  
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in protein ubiquitination  
    acts_upstream_of_or_within protein ubiquitination  
    involved_in regulation of aerobic respiration PubMed 
    involved_in regulation of apoptotic process  
    involved_in regulation of apoptotic process  
    involved_in regulation of cell migration PubMed 
    involved_in regulation of cell migration  
    involved_in regulation of glycogen biosynthetic process  
    involved_in regulation of myelination  
    acts_upstream_of_or_within regulation of myelination  
    involved_in regulation of neuron projection development  
    acts_upstream_of_or_within regulation of neuron projection development  
    involved_in regulation of neuron projection development  
    involved_in regulation of neuron projection development  
    involved_in regulation of postsynapse organization  
    involved_in regulation of postsynapse organization  
    acts_upstream_of_or_within regulation of protein localization PubMed 
    acts_upstream_of_or_within regulation of protein localization  
    involved_in regulation of protein localization  
    involved_in regulation of tRNA methylation  
    involved_in regulation of tRNA methylation  
    involved_in regulation of translation  
    involved_in response to UV-A  
    involved_in response to UV-A  
    involved_in response to fluid shear stress  
    involved_in response to fluid shear stress  
    involved_in response to food  
    acts_upstream_of_or_within response to food  
    involved_in response to growth factor  
    involved_in response to growth hormone  
    involved_in response to heat  
    involved_in response to heat  
    involved_in response to hormone  
    involved_in response to insulin-like growth factor stimulus  
    involved_in response to ischemia PubMed 
    involved_in response to muscle activity PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to oxidative stress  
    involved_in sphingosine-1-phosphate receptor signaling pathway  
    involved_in sphingosine-1-phosphate receptor signaling pathway  
    involved_in spinal cord development PubMed 
    involved_in striated muscle cell differentiation  
    acts_upstream_of_or_within striated muscle cell differentiation  
    involved_in translation PubMed 
    Items 1 - 25 of 258
    Items 1 - 20 of 34
    Component Evidence Code Pubs
    located_in cell-cell junction  
    located_in cell-cell junction  
    located_in ciliary basal body  
    located_in ciliary basal body  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    is_active_in membrane  
    located_in microtubule cytoskeleton  
    located_in mitochondrial intermembrane space  
    is_active_in mitochondrial intermembrane space  
    is_active_in mitochondrial intermembrane space  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of protein-containing complex  
    part_of protein-containing complex  
    located_in spindle  
    located_in spindle  
    located_in vesicle  
    located_in vesicle  
    Items 1 - 20 of 34

    General protein information

    Preferred Names
    RAC-alpha serine/threonine-protein kinase
    Names
    AKT1 kinase
    PKB alpha
    RAC protein kinase alpha RAC-PK alpha
    RAC-PK-alpha
    murine thymoma viral (v-akt) oncogene homolog 1
    protein kinase B alpha
    thymoma viral proto-oncogene 1
    v-akt murine thymoma viral oncogene homolog 1
    NP_150233.1
    XP_038967701.1
    XP_063117611.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033230.3NP_150233.1  RAC-alpha serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_150233.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P47196
      UniProtKB/TrEMBL
      A0A8L2QJ86, A6KBV9
      Related
      ENSRNOP00000090205.2, ENSRNOT00000114705.2
      Conserved Domains (2) summary
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05594
      Location:124479
      STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      137534810..137555131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111773.2XP_038967701.1  RAC-alpha serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      P47196
      UniProtKB/TrEMBL
      A0A8L2QJ86, A6KBV9
      Conserved Domains (2) summary
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05594
      Location:124479
      STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
    2. XM_063261541.1XP_063117611.1  RAC-alpha serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      P47196
      UniProtKB/TrEMBL
      A0A8L2QJ86, A6KBV9
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