Mnat1 MNAT1 component of CDK activating kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mnat1provided by RGD
Official Full Name: MNAT1 component of CDK activating kinaseprovided by RGD
Primary source: RGD:628874
See related: EnsemblRapid:ENSRNOG00000007267 AllianceGenome:RGD:628874
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and metal ion binding activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of apoptotic process; and positive regulation of smooth muscle cell proliferation. Predicted to be located in chromosome; cytoplasm; and nucleus. Predicted to be part of CAK-ERCC2 complex; RNA polymerase II transcription regulator complex; and cyclin-dependent protein kinase holoenzyme complex. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 166.7), Thymus (RPKM 116.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (97550566..97706598)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (91814703..91971945)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (95995341..96153331)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE120601 (e-PCR)
- UniSTS:247376

AI008314 (e-PCR)
- UniSTS:250526

D6Got118 (e-PCR)
- UniSTS:114402

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adult heart development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CAK-ERCC2 complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in germinal vesicle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIH core complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIH holo complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIH holo complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIK complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CDK-activating kinase assembly factor MAT1

Names: MNAT CDK-activating kinase assembly factor 1; MNAT1, CDK activating kinase assembly factor; menage a trois 1; menage a trois homolog 1, cyclin H assembly factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153472.2 → NP_703202.1 CDK-activating kinase assembly factor MAT1

See identical proteins and their annotated locations for NP_703202.1

Status: PROVISIONAL

Source sequence(s)

BC078712

UniProtKB/TrEMBL

A0A8I5ZYY1, A6HC54, Q6AZ68, Q8CIR5

Conserved Domains (1) summary

TIGR00570
Location:1 → 308

cdk7; CDK-activating kinase assembly factor MAT1