C2cd4a C2 calcium-dependent domain containing 4A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C2cd4aprovided by RGD
Official Full Name: C2 calcium-dependent domain containing 4Aprovided by RGD
Primary source: RGD:1596010
See related: EnsemblRapid:ENSRNOG00000034236 AllianceGenome:RGD:1596010
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nlf1; Fam148a
Summary: Predicted to be involved in positive regulation of acute inflammatory response; regulation of cell adhesion; and regulation of vascular permeability involved in acute inflammatory response. Predicted to be located in nucleolus and nucleoplasm. Orthologous to human C2CD4A (C2 calcium dependent domain containing 4A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 3.1), Brain (RPKM 2.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (77348161..77359996, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (68467017..68469781, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (73671516..73686344, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF408607 (e-PCR)
- UniSTS:248761

BF388554 (e-PCR)
- UniSTS:244984

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in positive regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular permeability involved in acute inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C2 calcium-dependent domain-containing protein 4A

Names: family with sequence similarity 148, member A; nuclear localized factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.