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    Krt86 keratin 86 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 407760, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krt86provided by RGD
    Official Full Name
    keratin 86provided by RGD
    Primary source
    RGD:1303215
    See related
    EnsemblRapid:ENSRNOG00000008367 AllianceGenome:RGD:1303215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kb26
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in hair disease and monilethrix. Orthologous to human KRT86 (keratin 86). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 36.3) See more
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    Genomic context

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    See Krt86 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134470224..134476873)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132591489..132598142)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143122285..143128932)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene keratin 88 Neighboring gene keratin 81 Neighboring gene keratin 83 Neighboring gene keratin 85

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix. Winter H, et al. Nat Genet, 1997 Aug. PMID 9241275
    2. The hairless phenotype of the Hirosaki hairless rat is due to the deletion of an 80-kb genomic DNA containing five basic keratin genes. Nanashima N, et al. J Biol Chem, 2008 Jun 13. PMID 18420582
    3. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952
    4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Pieragostino D, et al. Mol Biosyst, 2013 Jun. PMID 23580065
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type II cuticular Hb6
    Names
    keratin 86, type II
    type II keratin Kb26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008810.2 → NP_001008810.2  keratin, type II cuticular Hb6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2QC11
      Related
      ENSRNOP00000060052.4, ENSRNOT00000067422.6
      Conserved Domains (2) summary
      pfam00038
      Location:105 → 416
      Filament; Intermediate filament protein
      pfam16208
      Location:4 → 102
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      134470224..134476873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079713.1 → XP_038935641.1  keratin, type II cuticular Hb6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2QC11, A7M778, E9PT97, F7F801
      Conserved Domains (2) summary
      pfam00038
      Location:105 → 418
      Filament; Intermediate filament protein
      pfam16208
      Location:4 → 102
      Keratin_2_head; Keratin type II head
    Nucleotide Protein Strain
    Heading Accession and Version

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