Vps26a VPS26 retromer complex component A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vps26aprovided by RGD
Official Full Name: VPS26 retromer complex component Aprovided by RGD
Primary source: RGD:1359254
See related: EnsemblRapid:ENSRNOG00000030683 AllianceGenome:RGD:1359254
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vps26
Summary: Predicted to be involved in endocytic recycling; intracellular protein transport; and retrograde transport, endosome to Golgi. Located in cytosol. Part of retromer complex. Human ortholog(s) of this gene implicated in diabetic retinopathy and type 2 diabetes mellitus. Orthologous to human VPS26A (VPS26 retromer complex component A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 233.2), Heart (RPKM 155.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (30947018..30976964, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30404320..30434266, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (32085465..32115310, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VPS26A-SNX27 interaction plays a role in the development of neuropathic pain.
Title: VPS26A-SNX27 Interaction-Dependent mGluR5 Recycling in Dorsal Horn Neurons Mediates Neuropathic Pain in Rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140138 (e-PCR)
- UniSTS:222217

BE114352 (e-PCR)
- UniSTS:247474

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in endocytic recycling	IEA Inferred from Electronic Annotation more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
part_of retromer complex	IBA Inferred from Biological aspect of Ancestor more info
part_of retromer complex	IDA Inferred from Direct Assay more info	PubMed
part_of retromer complex	ISO Inferred from Sequence Orthology more info
part_of retromer, cargo-selective complex	IEA Inferred from Electronic Annotation more info
part_of retromer, cargo-selective complex	ISO Inferred from Sequence Orthology more info
located_in tubular endosome	IEA Inferred from Electronic Annotation more info
located_in tubular endosome	ISO Inferred from Sequence Orthology more info
located_in tubular endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: vacuolar protein sorting-associated protein 26A

Names: H beta 58; VPS26 retromer complex comonent A; vacuolar protein sorting 26 homolog A; vacuole protein sorting 26; vesicle protein sorting 26A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007740.1 → NP_001007741.1 vacuolar protein sorting-associated protein 26A

See identical proteins and their annotated locations for NP_001007741.1

Status: PROVISIONAL

Source sequence(s)

BC079150

UniProtKB/Swiss-Prot

Q6AY86

UniProtKB/TrEMBL

A0A0G2JXT0, A6K446

Related

ENSRNOP00000070391.3, ENSRNOT00000081916.3

Conserved Domains (1) summary

pfam03643
Location:8 → 283

Vps26; Vacuolar protein sorting-associated protein 26

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

30947018..30976964 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279302.1 → XP_063135372.1 vacuolar protein sorting-associated protein 26A isoform X3

UniProtKB/TrEMBL

A0A0G2JXT0
XM_039098876.2 → XP_038954804.1 vacuolar protein sorting-associated protein 26A isoform X5

Conserved Domains (1) summary

pfam03643
Location:9 → 163

Vps26; Vacuolar protein sorting-associated protein 26
XM_006256460.5 → XP_006256522.1 vacuolar protein sorting-associated protein 26A isoform X1

See identical proteins and their annotated locations for XP_006256522.1

UniProtKB/TrEMBL

A0A0G2JXT0, A0A8L2QWS2, A6K447

Related

ENSRNOP00000062170.2, ENSRNOT00000067883.4

Conserved Domains (1) summary

pfam03643
Location:40 → 315

Vps26; Vacuolar protein sorting-associated protein 26
XM_039098875.2 → XP_038954803.1 vacuolar protein sorting-associated protein 26A isoform X2

UniProtKB/TrEMBL

A0A0G2JXT0

Conserved Domains (1) summary

pfam03643
Location:40 → 275

Vps26; Vacuolar protein sorting-associated protein 26
XM_017601692.2 → XP_017457181.1 vacuolar protein sorting-associated protein 26A isoform X4

UniProtKB/TrEMBL

A6K449

Conserved Domains (1) summary

pfam03643
Location:2 → 172

Vps26; Vacuolar protein sorting-associated protein 26