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    Tdrd12 tudor domain containing 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689639, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tdrd12provided by RGD
    Official Full Name
    tudor domain containing 12provided by RGD
    Primary source
    RGD:1562792
    See related
    EnsemblRapid:ENSRNOG00000012719 AllianceGenome:RGD:1562792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562792
    Summary
    Predicted to enable ATP binding activity; hydrolase activity; and nucleic acid binding activity. Predicted to be involved in several processes, including germ-line stem cell division; male meiotic nuclear division; and regulatory ncRNA-mediated gene silencing. Predicted to be part of PET complex. Orthologous to human TDRD12 (tudor domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 58.6), Kidney (RPKM 15.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tdrd12 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (97270280..97342637, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (88133271..88205729, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91739126..91811577, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 89 Neighboring gene solute carrier family 7 member 9 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene nudix hydrolase 19 Neighboring gene regulator of G protein signaling 9 binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway. Yang Z, et al. Mol Cell, 2016 Jan 7. PMID 26669262, Free PMC Article
    2. Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Pandey RR, et al. Proc Natl Acad Sci U S A, 2013 Oct 8. PMID 24067652, Free PMC Article
    3. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in germ-line stem cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in piRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transposable element silencing by piRNA-mediated DNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PET complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    putative ATP-dependent RNA helicase TDRD12; tudor domain containing 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432607.1 → NP_001419536.1  tudor domain containing 12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZR00, F1LTR3

    2. NM_001432608.1 → NP_001419537.1  tudor domain containing 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AQS7, A6JAB5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      97270280..97342637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590063.3 → XP_017445552.1  putative ATP-dependent RNA helicase TDRD12 isoform X2

      Related
      ENSRNOP00000017021.5, ENSRNOT00000017021.8

    2. XM_063277999.1 → XP_063134069.1  putative ATP-dependent RNA helicase TDRD12 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZR00
      Related
      ENSRNOP00000080995.1, ENSRNOT00000113448.2

    3. XM_039100861.2 → XP_038956789.1  putative ATP-dependent RNA helicase TDRD12 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZR00
      Conserved Domains (4) summary
      cd06463
      Location:1120 → 1195
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      COG0513
      Location:369 → 803
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd20435
      Location:841 → 963
      Tudor_TDRD12_rpt2; second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins
      cl02573
      Location:9 → 112
      Tudor_SF; Tudor domain superfamily

    4. XM_063277978.1 → XP_063134048.1  putative ATP-dependent RNA helicase TDRD12 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR00

    5. XM_017590064.3 → XP_017445553.1  putative ATP-dependent RNA helicase TDRD12 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZR00

    6. XM_039100862.2 → XP_038956790.1  putative ATP-dependent RNA helicase TDRD12 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZR00
      Conserved Domains (3) summary
      cd06463
      Location:1012 → 1087
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      COG0513
      Location:261 → 695
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd20435
      Location:733 → 855
      Tudor_TDRD12_rpt2; second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins

    7. XM_039100863.2 → XP_038956791.1  putative ATP-dependent RNA helicase TDRD12 isoform X6

      Conserved Domains (3) summary
      cd06463
      Location:869 → 944
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      COG0513
      Location:118 → 552
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd20435
      Location:590 → 712
      Tudor_TDRD12_rpt2; second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins

    8. XM_039100864.2 → XP_038956792.1  putative ATP-dependent RNA helicase TDRD12 isoform X7

      Conserved Domains (3) summary
      cd06463
      Location:545 → 620
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cl38915
      Location:20 → 134
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
      cd20435
      Location:266 → 388
      Tudor_TDRD12_rpt2; second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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