Aktip AKT interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aktipprovided by RGD
Official Full Name: AKT interacting proteinprovided by RGD
Primary source: RGD:1311170
See related: EnsemblRapid:ENSRNOG00000011956 AllianceGenome:RGD:1311170
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fts
Summary: Predicted to enable NEDD8 transferase activity. Predicted to be involved in several processes, including early endosome to late endosome transport; protein localization to perinuclear region of cytoplasm; and protein neddylation. Predicted to act upstream of or within positive regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in cytosol and nucleus. Orthologous to human AKTIP (AKT interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 378.8), Brain (RPKM 292.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (32039507..32059634)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (15866811..15877123)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (17290048..17300054)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH142012 (e-PCR)
- UniSTS:224003

Aktip (e-PCR), detects polymorphism
- UniSTS:532291

AI501448 (e-PCR)
- UniSTS:226230

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in early endosome to late endosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome organization	IEA Inferred from Electronic Annotation more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in endosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome to lysosome transport	IEA Inferred from Electronic Annotation more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysosome organization	IEA Inferred from Electronic Annotation more info
involved_in lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in postreplication repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
involved_in protein localization to perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
involved_in protein localization to perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of FHF complex	IEA Inferred from Electronic Annotation more info
part_of FHF complex	ISO Inferred from Sequence Orthology more info
part_of FHF complex	ISS Inferred from Sequence or Structural Similarity more info
part_of HOPS complex	IEA Inferred from Electronic Annotation more info
part_of HOPS complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: AKT-interacting protein

Names: fused toes protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011926.1 → NP_001011926.1 AKT-interacting protein

See identical proteins and their annotated locations for NP_001011926.1

Status: PROVISIONAL

Source sequence(s)

BC089985

UniProtKB/Swiss-Prot

Q5FVH4

UniProtKB/TrEMBL

A0A8I6GA43, A6KD80

Related

ENSRNOP00000105243.1, ENSRNOT00000143979.1

Conserved Domains (1) summary

smart00212
Location:79 → 222

UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

32039507..32059634

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601205.3 → XP_017456694.1 AKT-interacting protein isoform X1

UniProtKB/TrEMBL

A0A8I6GA43
XM_017601206.2 → XP_017456695.1 AKT-interacting protein isoform X2

UniProtKB/TrEMBL

A0A8I6GA43

Related

ENSRNOP00000082936.2, ENSRNOT00000113279.2
XM_006255182.5 → XP_006255244.1 AKT-interacting protein isoform X3

See identical proteins and their annotated locations for XP_006255244.1

UniProtKB/TrEMBL

A0A8I6AQ33, A0A8I6GA43

Conserved Domains (2) summary

smart00212
Location:79 → 222

UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

COG5078
Location:79 → 218

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
XM_063277864.1 → XP_063133934.1 AKT-interacting protein isoform X4

UniProtKB/Swiss-Prot

Q5FVH4

UniProtKB/TrEMBL

A0A8I6GA43, A6KD80
XM_063277863.1 → XP_063133933.1 AKT-interacting protein isoform X3

UniProtKB/TrEMBL

A0A8I6AQ33, A0A8I6GA43

Related

ENSRNOP00000091269.1, ENSRNOT00000108713.2
XM_063277865.1 → XP_063133935.1 AKT-interacting protein isoform X5

UniProtKB/TrEMBL

A0A8I6AI00, A0A8I6GA43, A6KD77

Related

ENSRNOP00000092612.1, ENSRNOT00000109943.2
XM_039097569.2 → XP_038953497.1 AKT-interacting protein isoform X6

Conserved Domains (1) summary

smart00212
Location:2 → 138

UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues