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    Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286904, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cyp4f4provided by RGD
    Official Full Name
    cytochrome P450, family 4, subfamily f, polypeptide 4provided by RGD
    Primary source
    RGD:708363
    See related
    EnsemblRapid:ENSRNOG00000032895 AllianceGenome:RGD:708363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables arachidonate monooxygenase activity; heme binding activity; and leukotriene-B4 20-monooxygenase activity. Involved in icosanoid catabolic process; omega-hydroxylase P450 pathway; and response to 3-methylcholanthrene. Predicted to be located in endoplasmic reticulum membrane. Biomarker of hypertrophic cardiomyopathy. Orthologous to human CYP4F11 (cytochrome P450 family 4 subfamily F member 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 346.8) and Kidney (RPKM 14.4) See more
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    Genomic context

    See Cyp4f4 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (12367711..12384010)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11717208..11733507)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14891062..14907250)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A, pseudogene 4 Neighboring gene ferritin light chain 1 like 5 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 40 Neighboring gene RNA polymerase II-associated protein 3-like Neighboring gene uncharacterized LOC134479645 Neighboring gene uncharacterized LOC108351409

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane  
    located_in membrane  

    General protein information

    Preferred Names
    cytochrome P450 4F4
    Names
    CYPIVF4
    leukotriene-B4 20-monooxygenase
    NP_775146.1
    XP_063119146.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173123.1NP_775146.1  cytochrome P450 4F4

      See identical proteins and their annotated locations for NP_775146.1

      Status: PROVISIONAL

      Source sequence(s)
      U39206
      UniProtKB/Swiss-Prot
      P51869
      UniProtKB/TrEMBL
      A0A8L2ULC7, A6K957
      Related
      ENSRNOP00000039545.4, ENSRNOT00000041034.6
      Conserved Domains (1) summary
      cd20679
      Location:74515
      CYP4F; cytochrome P450 family 4, subfamily F

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      12367711..12384010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263076.1XP_063119146.1  cytochrome P450 4F4 isoform X1

      UniProtKB/TrEMBL
      A6K958
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