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    Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170911, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pik3caprovided by RGD
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alphaprovided by RGD
    Primary source
    RGD:620916
    See related
    EnsemblRapid:ENSRNOG00000056371 AllianceGenome:RGD:620916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including positive regulation of smooth muscle cell proliferation; response to L-leucine; and response to dexamethasone. Part of phosphatidylinositol 3-kinase complex. Biomarker of autosomal recessive polycystic kidney disease and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 217.1), Lung (RPKM 214.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pik3ca in Genome Data Viewer
    Location:
    2q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (117103643..117177411)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (115175275..115249034)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (118831350..118861456)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene zinc finger, matrin type 3 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3 Neighboring gene zinc finger protein 639

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC116320

    Gene Ontology Provided by RGD

    Items 1 - 25 of 31
    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity  
    enables 1-phosphatidylinositol-3-kinase activity PubMed 
    enables 1-phosphatidylinositol-3-kinase activity  
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity  
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity  
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity  
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables insulin receptor substrate binding  
    enables protein binding PubMed 
    enables protein kinase activator activity  
    enables protein serine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 31
    Items 1 - 25 of 42
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization  
    acts_upstream_of_or_within adipose tissue development  
    involved_in angiogenesis  
    acts_upstream_of_negative_effect autosome genomic imprinting  
    involved_in cardiac muscle cell contraction  
    involved_in cell migration  
    acts_upstream_of_or_within cellular response to glucose stimulus  
    involved_in cellular response to hydrostatic pressure  
    involved_in cellular response to insulin stimulus  
    acts_upstream_of_or_within energy homeostasis  
    acts_upstream_of_or_within glucose metabolic process  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    acts_upstream_of_or_within liver development  
    involved_in negative regulation of actin filament depolymerization  
    involved_in negative regulation of anoikis  
    acts_upstream_of_or_within negative regulation of fibroblast apoptotic process  
    involved_in negative regulation of gene expression PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process  
    involved_in phagocytosis  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol phosphate biosynthetic process PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process  
    involved_in phosphatidylinositol-mediated signaling  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein localization to membrane  
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in regulation of actin filament organization  
    acts_upstream_of_or_within regulation of cellular respiration  
    acts_upstream_of_or_within regulation of gene expression  
    acts_upstream_of_or_within regulation of multicellular organism growth  
    acts_upstream_of_or_within regulation of protein phosphorylation  
    involved_in relaxation of cardiac muscle  
    involved_in response to L-leucine PubMed 
    involved_in response to activity PubMed 
    involved_in response to butyrate PubMed 
    involved_in response to dexamethasone PubMed 
    involved_in response to muscle inactivity PubMed 
    involved_in response to muscle stretch  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 42
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in intercalated disc  
    located_in lamellipodium  
    part_of phosphatidylinositol 3-kinase complex PubMed 
    part_of phosphatidylinositol 3-kinase complex  
    part_of phosphatidylinositol 3-kinase complex, class IA  
    part_of phosphatidylinositol 3-kinase complex, class IA  
    part_of phosphatidylinositol 3-kinase complex, class IB  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Names
    PI3-kinase subunit alpha
    PI3K-alpha
    PI3Kalpha
    p110alpha
    phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
    phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
    phosphoinositide-3-kinase catalytic alpha polypeptide
    ptdIns-3-kinase subunit alpha
    ptdIns-3-kinase subunit p110-alpha
    serine/threonine protein kinase PIK3CA
    NP_596890.2
    XP_038957538.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133399.4NP_596890.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      A0A0G2K344
      Related
      ENSRNOP00000072496.1, ENSRNOT00000083720.3
      Conserved Domains (5) summary
      cd08398
      Location:325484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:31108
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:173292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:6951064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      117103643..117177411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101610.2XP_038957538.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/Swiss-Prot
      A0A0G2K344
      Conserved Domains (5) summary
      cd08398
      Location:325484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:31108
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:173292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:6951064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
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