Sh3bp1 SH3-domain binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sh3bp1provided by RGD
Official Full Name: SH3-domain binding protein 1provided by RGD
Primary source: RGD:1306275
See related: EnsemblRapid:ENSRNOG00000009360 AllianceGenome:RGD:1306275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTPase activator activity. Involved in cell migration; filopodium assembly; and positive regulation of GTPase activity. Located in cell leading edge. Orthologous to human SH3BP1 (SH3 domain binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 161.9), Spleen (RPKM 78.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (112338087..112350659)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (110457626..110470201)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (120125747..120138148)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SH3BP1 downregulates Rac1 at the motile-cell front and is required for cell motility.
Title: SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132918 (e-PCR)
- UniSTS:216201

RH130180 (e-PCR)
- UniSTS:213467

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables semaphorin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell apical/basal polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of small GTPase mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of small GTPase mediated signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of exocyst	ISO Inferred from Sequence Orthology more info
part_of exocyst	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SH3 domain-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171981.1 → NP_001165452.1 SH3 domain-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

D3ZFJ3

Related

ENSRNOP00000012480.3, ENSRNOT00000012480.7

Conserved Domains (2) summary

cd07620
Location:16 → 275

BAR_SH3BP1; The Bin/Amphiphysin/Rvs (BAR) domain of SH3-domain Binding Protein 1

cl02570
Location:272 → 473

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

112338087..112350659

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263317.1 → XP_063119387.1 SH3 domain-binding protein 1 isoform X1
XM_039078835.2 → XP_038934763.1 SH3 domain-binding protein 1 isoform X1

Conserved Domains (2) summary

cl02570
Location:208 → 409

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:1 → 211

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature