Stard13 StAR-related lipid transfer domain containing 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stard13provided by RGD
Official Full Name: StAR-related lipid transfer domain containing 13provided by RGD
Primary source: RGD:1564816
See related: EnsemblRapid:ENSRNOG00000001090 AllianceGenome:RGD:1564816
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564816
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Predicted to act upstream of or within several processes, including endothelial tube lumen extension; negative regulation of cell migration involved in sprouting angiogenesis; and negative regulation of sprouting angiogenesis. Predicted to be located in membrane. Orthologous to human STARD13 (StAR related lipid transfer domain containing 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 133.7), Liver (RPKM 88.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (5401878..5797937, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (566282..959372, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (1023494..1418919, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH140748 (e-PCR)
- UniSTS:222814

RH138797 (e-PCR)
- UniSTS:220884

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within angiogenesis involved in wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial tube lumen extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stAR-related lipid transfer protein 13

Names: StAR-related lipid transfer (START) domain containing 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109060.1 → NP_001102530.1 stAR-related lipid transfer protein 13

See identical proteins and their annotated locations for NP_001102530.1

Status: PROVISIONAL

Source sequence(s)

CH474108

UniProtKB/TrEMBL

A6KSV7, T2C9V6, T2CBG9

Conserved Domains (4) summary

cd08909
Location:900 → 1103

START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09592
Location:57 → 120

SAM_DLC2; SAM domain of STARD13-like subfamily

smart00454
Location:61 → 120

SAM; Sterile alpha motif

cd04375
Location:656 → 873

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

5401878..5797937 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598426.3 → XP_017453915.1 stAR-related lipid transfer protein 13 isoform X4

UniProtKB/TrEMBL

A0A8I6AGG1
XM_017598424.3 → XP_017453913.1 stAR-related lipid transfer protein 13 isoform X4

UniProtKB/TrEMBL

A0A8I6AGG1
XM_063271572.1 → XP_063127642.1 stAR-related lipid transfer protein 13 isoform X5

Related

ENSRNOP00000091607.2, ENSRNOT00000118613.2
XM_017598429.3 → XP_017453918.1 stAR-related lipid transfer protein 13 isoform X3
XM_017598428.3 → XP_017453917.1 stAR-related lipid transfer protein 13 isoform X2

UniProtKB/TrEMBL

A0A8I6AFY2

Related

ENSRNOP00000091608.1, ENSRNOT00000094162.2
XM_006248743.5 → XP_006248805.1 stAR-related lipid transfer protein 13 isoform X1

UniProtKB/TrEMBL

D3ZU63

Related

ENSRNOP00000001446.6, ENSRNOT00000001446.7

Conserved Domains (4) summary

cd08909
Location:919 → 1122

START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09592
Location:57 → 120

SAM_DLC2; SAM domain of STARD13-like subfamily

smart00454
Location:61 → 120

SAM; Sterile alpha motif

cd04375
Location:675 → 892

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
XM_039089673.2 → XP_038945601.1 stAR-related lipid transfer protein 13 isoform X9

Conserved Domains (2) summary

cd08909
Location:743 → 946

START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd04375
Location:499 → 716

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_063271573.1 → XP_063127643.1 stAR-related lipid transfer protein 13 isoform X8
XM_039089672.2 → XP_038945600.1 stAR-related lipid transfer protein 13 isoform X6

Conserved Domains (2) summary

cd08909
Location:801 → 1004

START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd04375
Location:557 → 774

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_006248749.5 → XP_006248811.1 stAR-related lipid transfer protein 13 isoform X6

See identical proteins and their annotated locations for XP_006248811.1

Conserved Domains (2) summary

cd08909
Location:801 → 1004

START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd04375
Location:557 → 774

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_008768991.3 → XP_008767213.1 stAR-related lipid transfer protein 13 isoform X7

Conserved Domains (2) summary

cd08909
Location:793 → 996

START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd04375
Location:549 → 766

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
XM_039089674.2 → XP_038945602.1 stAR-related lipid transfer protein 13 isoform X10

Conserved Domains (2) summary

cd09592
Location:57 → 120

SAM_DLC2; SAM domain of STARD13-like subfamily

cl02570
Location:675 → 704

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...