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    Zranb1 zinc finger RANBP2-type containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360606, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zranb1provided by RGD
    Official Full Name
    zinc finger RANBP2-type containing 1provided by RGD
    Primary source
    RGD:2321751
    See related
    EnsemblRapid:ENSRNOG00000017294 AllianceGenome:RGD:2321751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including positive regulation of Wnt signaling pathway; protein deubiquitination; and regulation of cell morphogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human ZRANB1 (zinc finger RANBP2-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 321.1), Muscle (RPKM 237.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zranb1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (197155048..197211518)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (187725354..187780129)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (204938444..205000163)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene abraxas 2, BRISC complex subunit Neighboring gene ribosomal protein S23, pseudogene 4 Neighboring gene uncharacterized LOC134483950 Neighboring gene C-terminal binding protein 2 Neighboring gene small ribosomal subunit protein eS21-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of two novel A20-like proteins. Evans PC, et al. Biochem J, 2001 Aug 1. PMID 11463333, Free PMC Article
    2. K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. Yuan WC, et al. Mol Cell, 2014 May 22. PMID 24768539
    3. Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Tran H, et al. Genes Dev, 2008 Feb 15. PMID 18281465, Free PMC Article
    4. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Mevissen TE, et al. Cell, 2013 Jul 3. PMID 23827681, Free PMC Article
    5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K29-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K33-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin thioesterase ZRANB1
    Names
    zinc finger, RAN-binding domain containing 1 protein-like
    NP_001414477.1
    XP_006230507.1
    XP_038957167.1
    XP_063137667.1
    XP_063137727.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427548.1 → NP_001414477.1  ubiquitin thioesterase ZRANB1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HX10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      197155048..197211518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281597.1 → XP_063137667.1  ubiquitin thioesterase ZRANB1 isoform X1

      UniProtKB/TrEMBL
      D4A3I0

    2. XM_006230445.5 → XP_006230507.1  ubiquitin thioesterase ZRANB1 isoform X1

      See identical proteins and their annotated locations for XP_006230507.1

      UniProtKB/TrEMBL
      D4A3I0
      Related
      ENSRNOP00000023257.5, ENSRNOT00000023257.9
      Conserved Domains (4) summary
      smart00547
      Location:178 → 201
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:114 → 133
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam02338
      Location:464 → 612
      OTU; OTU-like cysteine protease
      pfam18418
      Location:272 → 367
      AnkUBD; Ankyrin ubiquitin-binding domain

    3. XM_063281657.1 → XP_063137727.1  ubiquitin thioesterase ZRANB1 isoform X2

    4. XM_039101239.2 → XP_038957167.1  ubiquitin thioesterase ZRANB1 isoform X2

      Conserved Domains (1) summary
      pfam02338
      Location:112 → 260
      OTU; OTU-like cysteine protease
    Nucleotide Protein Strain
    Heading Accession and Version

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