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    Rhoj ras homolog family member J [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299145, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rhojprovided by RGD
    Official Full Name
    ras homolog family member Jprovided by RGD
    Primary source
    RGD:1310528
    See related
    EnsemblRapid:ENSRNOG00000021919 AllianceGenome:RGD:1310528
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; positive regulation of cell migration involved in sprouting angiogenesis; and regulation of sprouting angiogenesis. Predicted to act upstream of or within several processes, including Rho protein signal transduction; regulation of cell shape; and retina vasculature morphogenesis in camera-type eye. Predicted to be active in plasma membrane. Orthologous to human RHOJ (ras homolog family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 201.0), Lung (RPKM 180.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhoj in Genome Data Viewer
    Location:
    6q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (99771104..99853366)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (94035307..94117642)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (98284361..98367122)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550910 Neighboring gene synaptotagmin 16 Neighboring gene potassium voltage-gated channel subfamily H member 5 Neighboring gene protein phosphatase 2 regulatory subunit B', epsilon Neighboring gene glycoprotein hormone subunit beta 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TCL/RhoJ Plasma Membrane Localization and Nucleotide Exchange Is Coordinately Regulated by Amino Acids within the N Terminus and a Distal Loop Region. Ackermann KL, et al. J Biol Chem, 2016 Nov 4. PMID 27660391, Free PMC Article
    2. RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG. Yuan L, et al. Blood, 2011 Jul 28. PMID 21628409, Free PMC Article
    3. High-fat diet alters PP2A, TC10, and CIP4 expression in visceral adipose tissue of rats. Jun HS, et al. Obesity (Silver Spring), 2008 Jun. PMID 18388891
    4. Dysregulation of endothelial colony-forming cell function by a negative feedback loop of circulating miR-146a and -146b in cardiovascular disease patients. Chang TY, et al. PLoS One, 2017. PMID 28727754, Free PMC Article
    5. Role of glutamine synthetase in angiogenesis beyond glutamine synthesis. Eelen G, et al. Nature, 2018 Sep. PMID 30158707

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106003

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho-related GTP-binding protein RhoJ
    Names
    TC10-like Rho GTPase
    ras homolog gene family, member J

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008320.1 → NP_001008321.1  rho-related GTP-binding protein RhoJ

      See identical proteins and their annotated locations for NP_001008321.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086525
      UniProtKB/TrEMBL
      A0A8I5ZTS1, Q5RJS2
      Related
      ENSRNOP00000030536.3, ENSRNOT00000031979.6
      Conserved Domains (1) summary
      cl38936
      Location:22 → 195
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      99771104..99853366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112008.2 → XP_038967936.1  rho-related GTP-binding protein RhoJ isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJ60
      Related
      ENSRNOP00000095177.1, ENSRNOT00000099066.2
      Conserved Domains (1) summary
      cl38936
      Location:22 → 167
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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