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    Acadm acyl-CoA dehydrogenase medium chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24158, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acadmprovided by RGD
    Official Full Name
    acyl-CoA dehydrogenase medium chainprovided by RGD
    Primary source
    RGD:2012
    See related
    EnsemblRapid:ENSRNOG00000009845 AllianceGenome:RGD:2012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MCAD
    Summary
    Enables several functions, including acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding activity; and protein homodimerization activity. Involved in several processes, including fatty acid catabolic process; response to copper ion; and response to glucocorticoid. Located in mitochondrial matrix and mitochondrial membrane. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 2926.1), Muscle (RPKM 1889.4) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Acadm in Genome Data Viewer
    Location:
    2q45
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (245518693..245542864, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (242858865..242883036, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (260124418..260148589, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene small nucleolar RNA, C/D box 45A Neighboring gene small nucleolar RNA, C/D box 45C Neighboring gene small nucleolar RNA SNORA15 Neighboring gene uncharacterized LOC134485696 Neighboring gene solute carrier family 44, member 5 Neighboring gene uncharacterized LOC134485697

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in cardiac muscle cell differentiation  
    acts_upstream_of_or_within cardiac muscle cell differentiation  
    involved_in carnitine biosynthetic process  
    involved_in carnitine biosynthetic process  
    acts_upstream_of_or_within carnitine metabolic process  
    involved_in carnitine metabolic process, CoA-linked  
    involved_in carnitine metabolic process, CoA-linked  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase  
    involved_in glycogen biosynthetic process  
    involved_in glycogen biosynthetic process  
    acts_upstream_of_or_within heart development  
    involved_in liver development  
    acts_upstream_of_or_within liver development  
    involved_in medium-chain fatty acid catabolic process  
    involved_in medium-chain fatty acid catabolic process PubMed 
    involved_in medium-chain fatty acid catabolic process  
    involved_in medium-chain fatty acid catabolic process  
    involved_in medium-chain fatty acid metabolic process  
    acts_upstream_of_or_within organic acid metabolic process  
    involved_in post-embryonic development  
    acts_upstream_of_or_within post-embryonic development  
    involved_in regulation of gluconeogenesis  
    involved_in regulation of gluconeogenesis  
    involved_in response to cold  
    acts_upstream_of_or_within response to cold  
    involved_in response to copper ion PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to hormone PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to starvation  
    acts_upstream_of_or_within response to starvation  
    involved_in response to xenobiotic stimulus PubMed 
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    located_in axon  
    located_in axon  
    is_active_in cytoplasm  
    located_in mitochondrial matrix PubMed 
    located_in mitochondrial matrix  
    located_in mitochondrial matrix  
    located_in mitochondrial membrane PubMed 
    located_in mitochondrial membrane  
    located_in mitochondrial membrane  
    is_active_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    medium-chain specific acyl-CoA dehydrogenase, mitochondrial
    Names
    Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain
    acyl-CoA dehydrogenase, C-4 to C-12 straight chain
    acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
    acyl-Coenzyme A dehydrogenase, medium chain
    medium-chain acyl-CoA dehydrogenase
    NP_058682.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016986.2 → NP_058682.2  medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_058682.2

      Status: VALIDATED

      Source sequence(s)
      BP502473, CK359511, J02791, JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P08503
      UniProtKB/TrEMBL
      A6HWP6, G3V796
      Related
      ENSRNOP00000013238.1, ENSRNOT00000013238.5
      Conserved Domains (2) summary
      cd01157
      Location:41 → 418
      MCAD; Medium chain acyl-CoA dehydrogenase
      COG1960
      Location:39 → 420
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      245518693..245542864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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