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    Cp ceruloplasmin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24268, updated on 4-Jan-2025

    Summary

    Official Symbol
    Cpprovided by RGD
    Official Full Name
    ceruloplasminprovided by RGD
    Primary source
    RGD:2387
    See related
    EnsemblRapid:ENSRNOG00000011913 AllianceGenome:RGD:2387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CERP
    Summary
    Enables copper ion binding activity. Involved in several processes, including female pregnancy; mammary gland development; and response to copper ion. Located in cell surface and extracellular space. Used to study brain edema. Biomarker of Wilson disease; brain ischemia; heart disease; and hyperthyroidism. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Orthologous to human CP (ceruloplasmin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 6726.9), Spleen (RPKM 532.4) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    2q24
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (104368336..104427119)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (102439433..102498075)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (104744249..104803034)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial pseudogene Neighboring gene ribosome biogenesis regulator 1 homolog, pseudogene 9 Neighboring gene HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Neighboring gene uncharacterized LOC134485607 Neighboring gene helicase-like transcription factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables copper ion binding PubMed 
    enables copper ion binding  
    enables copper ion binding  
    enables ferroxidase activity  
    enables ferroxidase activity  
    enables glutathione peroxidase activity  
    enables glutathione peroxidase activity  
    enables oxidoreductase activity  
    enables oxidoreductase activity  
    enables oxidoreductase activity, acting on metal ions, oxygen as acceptor  
    enables oxidoreductase activity, acting on metal ions, oxygen as acceptor  
    enables phospholipid-hydroperoxide glutathione peroxidase activity  
    enables phospholipid-hydroperoxide glutathione peroxidase activity  
    enables protein-folding chaperone binding  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification  
    involved_in female pregnancy PubMed 
    involved_in intracellular copper ion homeostasis  
    involved_in intracellular copper ion homeostasis  
    involved_in intracellular iron ion homeostasis  
    involved_in intracellular iron ion homeostasis  
    involved_in intracellular iron ion homeostasis PubMed 
    involved_in iron ion transport  
    involved_in lactation PubMed 
    involved_in liver development PubMed 
    involved_in lung development PubMed 
    involved_in mammary gland involution PubMed 
    involved_in plasma membrane copper ion transport PubMed 
    involved_in response to copper ion PubMed 
    involved_in response to nutrient PubMed 
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    located_in extracellular region  
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    ceruloplasmin
    Names
    bilitranslocase
    ceruloplasmin (ferroxidase)
    cuproxidase ceruloplasmin
    ferroxidase ceruloplasmin
    glutathione peroxidase ceruloplasmin
    glutathione-dependent peroxiredoxin ceruloplasmin
    NP_001257890.1
    NP_036664.2
    XP_063137357.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270961.1NP_001257890.1  ceruloplasmin isoform 2 precursor

      See identical proteins and their annotated locations for NP_001257890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains two alternate 3' exons compared to variant 1. The resulting protein (isoform 2), which is longer and has a distinct C-terminus compared to isoform 1, is a glycosylphosphatidylinositol-anchored form.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6A708, A6IHC3, Q9JL97
      Related
      ENSRNOP00000089330.1, ENSRNOT00000119964.2
      Conserved Domains (5) summary
      cd04225
      Location:726896
      CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
      cd11012
      Location:9071051
      CuRO_6_ceruloplasmin; The sixth cupredoxin domain of Ceruloplasmin
      cd11021
      Location:213353
      CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
      cd11022
      Location:569712
      CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
      cl19115
      Location:369566
      Cupredoxin; Cupredoxin superfamily
    2. NM_012532.2NP_036664.2  ceruloplasmin isoform 1 precursor

      See identical proteins and their annotated locations for NP_036664.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes a secreted protein (isoform 1).
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P13635, Q64719
      UniProtKB/TrEMBL
      A6IHC4, G3V7K3
      Related
      ENSRNOP00000016083.4, ENSRNOT00000016083.7
      Conserved Domains (5) summary
      cd04225
      Location:726896
      CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
      cd11012
      Location:9071051
      CuRO_6_ceruloplasmin; The sixth cupredoxin domain of Ceruloplasmin
      cd11021
      Location:213353
      CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
      cd11022
      Location:569712
      CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
      cl19115
      Location:369566
      Cupredoxin; Cupredoxin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      104368336..104427119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281287.1XP_063137357.1  ceruloplasmin isoform X1

      UniProtKB/TrEMBL
      A0A8I6A708, A6IHC3, Q9JL97

    RNA

    1. XR_590972.4 RNA Sequence

      Related
      ENSRNOT00000082627.3
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