U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29680, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cyp11a1provided by RGD
    Official Full Name
    cytochrome P450, family 11, subfamily a, polypeptide 1provided by RGD
    Primary source
    RGD:69325
    See related
    EnsemblRapid:ENSRNOG00000008074 AllianceGenome:RGD:69325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp11a; Cypxia1; P450scc; P450(scc)
    Summary
    Predicted to enable cholesterol monooxygenase (side-chain-cleaving) activity and heme binding activity. Involved in several processes, including cellular response to cytokine stimulus; nervous system development; and steroid biosynthetic process. Located in mitochondrial crista and perikaryon. Biomarker of several diseases, including glucose metabolism disease (multiple); hypertension; nephrosis; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 27876.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cyp11a1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (67318665..67330196)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (58422807..58434342)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62798317..62809848)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480057 Neighboring gene semaphorin 7A (John Milton Hagen blood group) Neighboring gene uncharacterized LOC134480058 Neighboring gene uncharacterized LOC103693105 Neighboring gene coiled-coil domain containing 33 Neighboring gene uncharacterized LOC120094173 Neighboring gene signaling receptor and transporter of retinol STRA6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol monooxygenase (side-chain-cleaving) activity  
    enables cholesterol monooxygenase (side-chain-cleaving) activity  
    enables cholesterol monooxygenase (side-chain-cleaving) activity  
    enables cholesterol monooxygenase (side-chain-cleaving) activity PubMed 
    enables heme binding  
    enables heme binding  
    enables heme binding  
    enables iron ion binding  
    Items 1 - 25 of 62
    Process Evidence Code Pubs
    involved_in C21-steroid hormone biosynthetic process  
    involved_in C21-steroid hormone biosynthetic process PubMed 
    involved_in C21-steroid hormone biosynthetic process  
    acts_upstream_of_or_within C21-steroid hormone biosynthetic process  
    involved_in C21-steroid hormone biosynthetic process  
    involved_in C21-steroid hormone metabolic process  
    involved_in Leydig cell differentiation PubMed 
    involved_in Schwann cell differentiation PubMed 
    involved_in biphenyl metabolic process PubMed 
    involved_in cellular response to antibiotic PubMed 
    involved_in cellular response to cAMP PubMed 
    involved_in cellular response to cadmium ion PubMed 
    involved_in cellular response to fibroblast growth factor stimulus PubMed 
    involved_in cellular response to follicle-stimulating hormone stimulus PubMed 
    involved_in cellular response to gonadotropin stimulus PubMed 
    involved_in cellular response to interleukin-1 PubMed 
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to peptide hormone stimulus  
    involved_in cellular response to peptide hormone stimulus PubMed 
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in cerebellum development PubMed 
    involved_in cholesterol metabolic process  
    involved_in cholesterol metabolic process  
    involved_in cholesterol metabolic process  
    involved_in cholesterol metabolic process  
    involved_in cortisol metabolic process  
    involved_in dibenzo-p-dioxin metabolic process PubMed 
    involved_in glucocorticoid biosynthetic process  
    involved_in granulosa cell differentiation PubMed 
    involved_in hippocampus development PubMed 
    involved_in hormone biosynthetic process  
    involved_in male gonad development PubMed 
    involved_in maternal process involved in female pregnancy PubMed 
    involved_in mating behavior PubMed 
    involved_in organic acid metabolic process PubMed 
    involved_in phenol-containing compound metabolic process PubMed 
    involved_in phthalate metabolic process PubMed 
    involved_in response to L-ascorbic acid PubMed 
    involved_in response to alkaloid PubMed 
    involved_in response to amino acid PubMed 
    involved_in response to cAMP PubMed 
    involved_in response to cadmium ion PubMed 
    involved_in response to corticosterone PubMed 
    involved_in response to estrogen PubMed 
    involved_in response to fungicide PubMed 
    involved_in response to gamma radiation PubMed 
    involved_in response to genistein PubMed 
    involved_in response to gonadotropin PubMed 
    involved_in response to hydrogen peroxide PubMed 
    involved_in response to insecticide PubMed 
    involved_in response to ionizing radiation PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to peptide hormone PubMed 
    involved_in response to salt stress PubMed 
    involved_in response to steroid hormone PubMed 
    involved_in response to vitamin E PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in steroid biosynthetic process  
    involved_in steroid biosynthetic process PubMed 
    involved_in testosterone biosynthetic process PubMed 
    Items 1 - 25 of 62
    Component Evidence Code Pubs
    located_in mitochondrial crista PubMed 
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in perikaryon PubMed 

    General protein information

    Preferred Names
    cholesterol side-chain cleavage enzyme, mitochondrial
    Names
    cholesterol desmolase
    cholesterol side-chain cleavage cytochrome P450
    cytochrome P450 11A1
    cytochrome P450 11a cholesterol side chain cleavage
    cytochrome P450 family 11 subfamily a
    cytochrome P450 side-chain cleavage enzyme
    cytochrome P450 subfamily 11A
    cytochrome P450(scc)
    NP_058982.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017286.3NP_058982.1  cholesterol side-chain cleavage enzyme, mitochondrial precursor

      See identical proteins and their annotated locations for NP_058982.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P14137, Q5FWY8, Q6LDR9
      UniProtKB/TrEMBL
      A0A8I6AA11, A6J4Y6
      Related
      ENSRNOP00000088079.1, ENSRNOT00000106594.2
      Conserved Domains (1) summary
      cl41757
      Location:80505
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      67318665..67330196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.