Plscr1 phospholipid scramblase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plscr1provided by RGD
Official Full Name: phospholipid scramblase 1provided by RGD
Primary source: RGD:620521
See related: EnsemblRapid:ENSRNOG00000008048 AllianceGenome:RGD:620521
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables enzyme binding activity. Involved in several processes, including plasma membrane phospholipid scrambling; regulation of Fc receptor mediated stimulatory signaling pathway; and regulation of mast cell activation. Located in membrane raft and plasma membrane. Orthologous to human PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 160.4), Kidney (RPKM 154.8) and 8 other tissues See more
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Genomic context

Location:: 8q31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (101662512..101684474)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (92784279..92804698)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (99625523..99645882)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study reveals a complex regulation for PLSCR1 tyrosine phosphorylation in FcepsilonRI-activated mast cells, and that PLSCR1 sits at a crossroads between Lyn and Fyn pathways.
Title: Regulation of the tyrosine phosphorylation of Phospholipid Scramblase 1 in mast cells that are stimulated through the high-affinity IgE receptor.
PLSCR1 is a novel amplifier of FcepsilonRI signaling that acts selectively on the Lyn-initiated LAT/phospholipase Cgamma1/calcium axis, resulting in potentiation of a selected set of mast cell responses
Title: Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway.
changes in the topography of PLSCR1 and its tyrosine phosphorylation, PS externalization, and exocytosis are independent phenomena that could be distinguished by employing specific conditions of activation
Title: Engagement of phospholipid scramblase 1 in activated cells: implication for phosphatidylserine externalization and exocytosis.

Submit: New GeneRIF Correction

General gene information

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Markers

AI237617 (e-PCR)
- UniSTS:250690

RH143342 (e-PCR)
- UniSTS:232589

RH141661 (e-PCR)
- UniSTS:223654

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CD4 receptor binding	ISO Inferred from Sequence Orthology more info
enables CD4 receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables lead ion binding	ISO Inferred from Sequence Orthology more info
enables lead ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables mercury ion binding	ISO Inferred from Sequence Orthology more info
enables mercury ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclease activity	ISO Inferred from Sequence Orthology more info
enables nuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid scramblase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid scramblase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables phospholipid scramblase activity	ISS Inferred from Sequence or Structural Similarity more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acute-phase response	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylserine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine exposure on apoptotic cell surface	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylserine exposure on apoptotic cell surface	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine exposure on apoptotic cell surface	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine exposure on apoptotic cell surface	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid transport	TAS Traceable Author Statement more info	PubMed
involved_in plasma membrane phospholipid scrambling	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane phospholipid scrambling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane phospholipid scrambling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome separation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome separation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Fc receptor mediated stimulatory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mast cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in response to lead ion	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phospholipid scramblase 1

Names: PL scramblase 1; ca(2+)-dependent phospholipid scramblase 1; mg(2+)-dependent nuclease; phospholipid scramblase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.