U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Kcnc3 potassium voltage-gated channel subfamily C member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117101, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnc3provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily C member 3provided by RGD
    Primary source
    RGD:621358
    See related
    EnsemblRapid:ENSRNOG00000019959 AllianceGenome:RGD:621358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv3.3; KShIIID
    Summary
    Enables voltage-gated potassium channel activity. Involved in corpus callosum development and optic nerve development. Located in dendrite. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 13. Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 32.8), Lung (RPKM 9.8) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kcnc3 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104217472..104231677)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95080960..95095165)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100593453..100607874)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 1, group H, member 2 Neighboring gene napsin A aspartic peptidase Neighboring gene myosin heavy chain 14 Neighboring gene ribosomal protein L19, pseudogene 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity  
    enables metal ion binding  
    enables voltage-gated potassium channel activity PubMed 
    enables voltage-gated potassium channel activity  
    enables voltage-gated potassium channel activity  
    enables voltage-gated potassium channel activity  
    Process Evidence Code Pubs
    involved_in action potential  
    involved_in corpus callosum development PubMed 
    involved_in cortical actin cytoskeleton organization  
    involved_in cortical actin cytoskeleton organization  
    involved_in cortical actin cytoskeleton organization  
    involved_in optic nerve development PubMed 
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transport  
    involved_in potassium ion transport  
    involved_in protein homooligomerization  
    involved_in protein tetramerization  
    involved_in protein tetramerization  
    involved_in protein tetramerization  
    acts_upstream_of_or_within regulation of neurotransmitter secretion  
    involved_in regulation of synaptic vesicle endocytosis  
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    located_in axolemma  
    is_active_in axon terminus  
    located_in axon terminus  
    is_active_in calyx of Held  
    located_in cell cortex  
    located_in cell cortex  
    located_in cytoskeleton  
    located_in dendrite PubMed 
    located_in dendrite  
    located_in dendrite  
    is_active_in dendrite membrane  
    located_in dendrite membrane  
    located_in dendritic spine membrane  
    is_active_in glutamatergic synapse PubMed 
    located_in neuromuscular junction  
    located_in neuron projection  
    is_active_in neuronal cell body membrane  
    located_in neuronal cell body membrane  
    located_in perikaryon  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic membrane  
    is_active_in postsynaptic membrane PubMed 
    is_active_in presynaptic membrane  
    is_active_in presynaptic membrane PubMed 
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex  
    Items 1 - 20 of 29

    General protein information

    Preferred Names
    voltage-gated potassium channel KCNC3
    Names
    potassium channel, voltage gated Shaw-related subfamily C, member 3
    potassium voltage gated channel, Shaw-related subfamily, member 3
    voltage-gated potassium channel subunit Kv3.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053997.5NP_446449.2  voltage-gated potassium channel KCNC3

      See identical proteins and their annotated locations for NP_446449.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8J8XF86, F1MAD4, Q811T3
      Related
      ENSRNOP00000027063.5, ENSRNOT00000027063.9
      Conserved Domains (4) summary
      smart00225
      Location:92194
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:344551
      Ion_trans; Ion transport protein
      pfam02214
      Location:92186
      BTB_2; BTB/POZ domain
      pfam07885
      Location:460541
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104217472..104231677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.