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    Cngb1 cyclic nucleotide gated channel subunit beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83686, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cngb1provided by RGD
    Official Full Name
    cyclic nucleotide gated channel subunit beta 1provided by RGD
    Primary source
    RGD:621809
    See related
    EnsemblRapid:ENSRNOG00000031773 AllianceGenome:RGD:621809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CNG4; CNG-4; Gm1959
    Summary
    Enables cyclic nucleotide binding activity and intracellularly cyclic nucleotide-activated monoatomic cation channel activity. Involved in metal ion transport and regulation of cytosolic calcium ion concentration. Located in non-motile cilium membrane and terminal bouton. Part of intracellular cyclic nucleotide activated cation channel complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 45. Orthologous to human CNGB1 (cyclic nucleotide gated channel subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 3.0), Spleen (RPKM 0.8) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Cngb1 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9732646..9798864)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9726595..9791111)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10142440..10206618)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 319 Neighboring gene sperm microtubule inner protein 8 Neighboring gene RNA, U2 small nuclear 69, pseudogene Neighboring gene kinesin family member C3 Neighboring gene uncharacterized LOC134483686 Neighboring gene katanin regulatory subunit B1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cAMP binding PubMed 
    enables cAMP binding  
    enables cGMP binding  
    enables cGMP binding PubMed 
    enables cGMP binding  
    enables calcium channel activity  
    enables cyclic nucleotide-activated monoatomic ion channel activity  
    enables intracellularly cAMP-activated cation channel activity  
    enables intracellularly cAMP-activated cation channel activity PubMed 
    enables intracellularly cAMP-activated cation channel activity  
    enables intracellularly cGMP-activated cation channel activity  
    enables intracellularly cGMP-activated cation channel activity PubMed 
    enables intracellularly cGMP-activated cation channel activity  
    enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity PubMed 
    enables protein-containing complex binding  
    enables protein-containing complex binding PubMed 
    enables sodium channel activity  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transport PubMed 
    involved_in detection of light stimulus involved in visual perception  
    involved_in monoatomic cation transmembrane transport  
    involved_in monoatomic cation transmembrane transport  
    involved_in monoatomic cation transport  
    acts_upstream_of_or_within photoreceptor cell maintenance  
    acts_upstream_of_or_within photoreceptor cell outer segment organization  
    acts_upstream_of_or_within phototransduction  
    involved_in potassium ion transport PubMed 
    acts_upstream_of_or_within protein localization to organelle  
    involved_in regulation of cytosolic calcium ion concentration PubMed 
    involved_in retina homeostasis  
    involved_in retina homeostasis  
    acts_upstream_of_or_within sensory perception of smell  
    acts_upstream_of_or_within sensory perception of smell  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transport PubMed 
    involved_in visual perception  
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex  
    part_of intracellular cyclic nucleotide activated cation channel complex PubMed 
    located_in membrane  
    located_in non-motile cilium membrane PubMed 
    located_in non-motile cilium membrane  
    is_active_in photoreceptor outer segment  
    located_in photoreceptor outer segment  
    is_active_in plasma membrane  
    located_in rod photoreceptor outer segment  
    located_in terminal bouton PubMed 
    part_of transmembrane transporter complex  

    General protein information

    Preferred Names
    cyclic nucleotide-gated channel beta-1; cyclic nucleotide-gated cation channel beta-1
    Names
    CNG channel 4
    cyclic nucleotide gated channel beta 1
    cyclic nucleotide-gated cation channel 4
    cyclic nucleotide-gated channel beta subunit 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389260.1NP_001376189.1  cyclic nucleotide-gated channel beta-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      O55150
    2. NM_031809.2NP_113997.2  cyclic nucleotide-gated channel beta-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      O35788
      Related
      ENSRNOP00000079558.2, ENSRNOT00000109711.2
      Conserved Domains (2) summary
      PLN03192
      Location:7431129
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:10571166
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      9732646..9798864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278317.1XP_063134387.1  cyclic nucleotide-gated cation channel beta-1 isoform X1

      UniProtKB/TrEMBL
      A6JY21
      Related
      ENSRNOP00000073715.1, ENSRNOT00000085440.3
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