Tp63 tumor protein p63 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tp63provided by RGD
Official Full Name: tumor protein p63provided by RGD
Primary source: RGD:620863
See related: EnsemblRapid:ENSRNOG00000001924 AllianceGenome:RGD:620863
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ket; P73l; Tp73l; Trp63
Summary: This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
Expression: Biased expression in Thymus (RPKM 17.0), Muscle (RPKM 14.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (88343647..88554543, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (74838858..75049764, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (78234853..78456559, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The pro-survival response of neurons, initiated through the rapid induction of p63, is mediated ultimately by the transcriptional repression of a pro-apoptotic isoform of p73 by ZEB1.
Title: ZEB1 links p63 and p73 in a novel neuronal survival pathway rapidly induced in response to cortical ischemia.
expressed in stem cells and young transient amplifying cells of the rat cornea, with higher levels of expression in the latter
Title: Age-related expressions of p63 and other keratinocyte stem cell markers in rat cornea.

Submit: New GeneRIF Correction

General gene information

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Markers

D11Wox15 (e-PCR)
- UniSTS:518657

Trp63 (e-PCR), detects polymorphism
- UniSTS:257030

Trp63 (e-PCR), detects polymorphism
- UniSTS:144677

PMC25851P2 (e-PCR)
- UniSTS:272289

AU049641 (e-PCR)
- UniSTS:146087

Trp63 (e-PCR), detects polymorphism
- UniSTS:499117

Trp63 (e-PCR), detects polymorphism
- UniSTS:526811

Trp63 (e-PCR), detects polymorphism
- UniSTS:526812

Trp63 (e-PCR), detects polymorphism
- UniSTS:256989

Trp63 (e-PCR), detects polymorphism
- UniSTS:256990

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables MDM2/MDM4 family protein binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cloacal septation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cranial skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ectoderm and mesoderm interaction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic limb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermal cell division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermis development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of planar polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within female genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of a polarized epithelium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mesoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within polarized epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-anal tail morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostatic bud formation	ISO Inferred from Sequence Orthology more info
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proximal/distal pattern formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of epidermal cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin epidermis development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sympathetic nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: tumor protein 63

Names: keratinocyte transcription factor KET; transformation related protein 63; tumor protein 63 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127339.2 → NP_001120811.1 tumor protein 63 isoform b

See identical proteins and their annotated locations for NP_001120811.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal exon in the 3' region, as compared to variant 1. The resulting isoform (b, also known as TA2KETbeta) has a shorter and different C-terminus, as compared to isoform a.

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q9JJP6

Related

ENSRNOP00000059178.3, ENSRNOT00000067251.6

Conserved Domains (3) summary

pfam08430
Location:452 → 534

Forkhead_N; Forkhead N-terminal region

pfam00870
Location:163 → 358

P53; P53 DNA-binding domain

pfam07710
Location:391 → 431

P53_tetramer; P53 tetramerization motif
NM_001127341.1 → NP_001120813.1 tumor protein 63 isoform c

See identical proteins and their annotated locations for NP_001120813.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (c, also known as TA2KETgamma) has a shorter and different C-terminus, as compared to isoform a.

Source sequence(s)

AJ277449, Y10258

UniProtKB/TrEMBL

A6JRZ6

Related

ENSRNOP00000032308.4, ENSRNOT00000036179.7

Conserved Domains (2) summary

cd08367
Location:177 → 358

P53; P53 DNA-binding domain

pfam07710
Location:392 → 428

P53_tetramer; P53 tetramerisation motif
NM_001127342.3 → NP_001120814.1 tumor protein 63 isoform d

See identical proteins and their annotated locations for NP_001120814.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) is an alternate promoter product; it lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (d, also known as deltaNKETalpha) has a shorter and different N-terminus, as compared to isoform a.

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6JRZ5

Related

ENSRNOP00000002636.4, ENSRNOT00000002636.9

Conserved Domains (5) summary

cd09572
Location:449 → 513

SAM_tumor-p63; SAM domain of tumor-p63 proteins

smart00454
Location:447 → 512

SAM; Sterile alpha motif

pfam08430
Location:358 → 440

Forkhead_N; Forkhead N-terminal region

pfam00870
Location:69 → 264

P53; P53 DNA-binding domain

pfam07710
Location:297 → 337

P53_tetramer; P53 tetramerization motif
NM_001127343.3 → NP_001120815.1 tumor protein 63 isoform e

See identical proteins and their annotated locations for NP_001120815.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) is an alternate promoter product; it lacks several 5' exons and an internal exon in the 3' region, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (e, also known as deltaNKETbeta) has shorter and different N- and C-termini, as compared to isoform a.

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q9JJP6

Conserved Domains (2) summary

pfam00870
Location:69 → 264

P53; P53 DNA-binding domain

pfam07710
Location:297 → 337

P53_tetramer; P53 tetramerization motif
NM_001127344.2 → NP_001120816.1 tumor protein 63 isoform f

See identical proteins and their annotated locations for NP_001120816.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) is an alternate promoter product; it lacks several 5' and 3' exons, but has alternate 5' and 3' exons, as compared to variant 1. The resulting isoform (f, also known as deltaNKETgamma) has shorter and different N- and C-termini, as compared to isoform a.

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6JRZ7

Conserved Domains (2) summary

pfam00870
Location:69 → 264

P53; P53 DNA-binding domain

pfam07710
Location:297 → 337

P53_tetramer; P53 tetramerization motif
NM_019221.4 → NP_062094.1 tumor protein 63 isoform a

See identical proteins and their annotated locations for NP_062094.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a, also known as TA2KETalpha).

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q99JD6, Q99JD7, Q99JD8, Q99JD9, Q99JE0, Q99JE1, Q99JE2, Q99JE3, Q9JJP6

UniProtKB/TrEMBL

A6JRZ4

Related

ENSRNOP00000061884.4, ENSRNOT00000068116.6

Conserved Domains (3) summary

cd08367
Location:177 → 358

P53; P53 DNA-binding domain

cd09572
Location:543 → 607

SAM_tumor-p63; SAM domain of tumor-p63 proteins

pfam07710
Location:392 → 428

P53_tetramer; P53 tetramerisation motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

88343647..88554543 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597881.3 → XP_017453370.1 tumor protein 63 isoform X1
XM_063270286.1 → XP_063126356.1 tumor protein 63 isoform X2
XM_063270287.1 → XP_063126357.1 tumor protein 63 isoform X3
XM_006248500.5 → XP_006248562.1 tumor protein 63 isoform X4

Conserved Domains (2) summary

cd08367
Location:177 → 358

P53; P53 DNA-binding domain

pfam07710
Location:388 → 424

P53_tetramer; P53 tetramerisation motif
XM_063270288.1 → XP_063126358.1 tumor protein 63 isoform X5