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    Tubb3 tubulin, beta 3 class III [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246118, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tubb3provided by RGD
    Official Full Name
    tubulin, beta 3 class IIIprovided by RGD
    Primary source
    RGD:628595
    See related
    EnsemblRapid:ENSRNOG00000017209 AllianceGenome:RGD:628595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables peptide binding activity. Involved in neuron differentiation. Located in axon. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 1 and congenital fibrosis of the extraocular muscles 3A. Orthologous to human TUBB3 (tubulin beta 3 class III). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 1330.7), Testes (RPKM 116.2) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Tubb3 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68365687..68374741)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51457187..51466243)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56220759..56229813)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene TCF25 ribosome quality control complex subunit Neighboring gene melanocortin 1 receptor Neighboring gene U5 spliceosomal RNA Neighboring gene differentially expressed in FDCP 8 homolog Neighboring gene AFG3 (ATPase family gene 3)-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables metal ion binding  
    enables netrin receptor binding  
    enables peptide binding PubMed 
    enables protein binding PubMed 
    enables structural constituent of cytoskeleton  
    enables structural constituent of cytoskeleton  
    enables structural constituent of cytoskeleton  
    enables structural constituent of cytoskeleton PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance  
    involved_in axon guidance  
    involved_in axon guidance  
    involved_in dorsal root ganglion development  
    involved_in dorsal root ganglion development  
    involved_in microtubule cytoskeleton organization  
    involved_in microtubule cytoskeleton organization  
    involved_in microtubule cytoskeleton organization  
    involved_in mitotic cell cycle  
    involved_in netrin-activated signaling pathway  
    involved_in netrin-activated signaling pathway  
    involved_in neuron differentiation PubMed 
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    located_in axon PubMed 
    located_in axon  
    located_in cell periphery  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in dendrite  
    located_in dendrite  
    located_in filopodium  
    located_in filopodium  
    located_in growth cone  
    located_in growth cone  
    located_in intercellular bridge  
    located_in intercellular bridge  
    located_in lamellipodium  
    located_in lamellipodium  
    is_active_in microtubule  
    located_in microtubule  
    is_active_in microtubule cytoskeleton  
    located_in microtubule cytoskeleton  
    is_active_in microtubule cytoskeleton  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in motile cilium  
    located_in neuronal cell body  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    tubulin beta-3 chain
    Names
    neuron-specific class III beta-tubulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139254.2NP_640347.2  tubulin beta-3 chain

      See identical proteins and their annotated locations for NP_640347.2

      Status: VALIDATED

      Source sequence(s)
      BC097281, CF976541
      UniProtKB/Swiss-Prot
      Q4QRB4, Q6P9T8, Q8K5B6
      UniProtKB/TrEMBL
      A6IZY2
      Related
      ENSRNOP00000023452.3, ENSRNOT00000023452.8
      Conserved Domains (1) summary
      PLN00220
      Location:1447
      PLN00220; tubulin beta chain; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      68365687..68374741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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