Rasgrp2 RAS guanyl releasing protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rasgrp2provided by RGD
Official Full Name: RAS guanyl releasing protein 2provided by RGD
Primary source: RGD:1311630
See related: EnsemblRapid:ENSRNOG00000021098 AllianceGenome:RGD:1311630
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction; cellular response to calcium ion; and positive regulation of GTPase activity. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 18. Orthologous to human RASGRP2 (RAS guanyl releasing protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 149.7), Thymus (RPKM 118.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213135034..213152246)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (203705777..203722993)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (221771238..221788765)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Rasgrp2 (e-PCR), detects polymorphism
- UniSTS:508520

RH131404 (e-PCR)
- UniSTS:214687

Rasgrp2 (e-PCR), detects polymorphism
- UniSTS:528305

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RAS guanyl-releasing protein 2

Names: RAS guanyl releasing protein 2 (calcium and DAG-regulated); calDAG-GEFI; calcium and DAG-regulated guanine nucleotide exchange factor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082977.2 → NP_001076446.2 RAS guanyl-releasing protein 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd20861
Location:496 → 551

C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

213135034..213152246

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230854.5 → XP_006230916.1 RAS guanyl-releasing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006230916.1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd20861
Location:496 → 551

C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
XM_063268258.1 → XP_063124328.1 RAS guanyl-releasing protein 2 isoform X1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1
XM_063268277.1 → XP_063124347.1 RAS guanyl-releasing protein 2 isoform X1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1
XM_063268267.1 → XP_063124337.1 RAS guanyl-releasing protein 2 isoform X1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1
XM_063268269.1 → XP_063124339.1 RAS guanyl-releasing protein 2 isoform X1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1
XM_039083977.2 → XP_038939905.1 RAS guanyl-releasing protein 2 isoform X1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd20861
Location:496 → 551

C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
XM_006230853.3 → XP_006230915.1 RAS guanyl-releasing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006230915.1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd20861
Location:496 → 551

C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
XM_039084004.1 → XP_038939932.1 RAS guanyl-releasing protein 2 isoform X3

UniProtKB/TrEMBL

A6HZH4

Related

ENSRNOP00000102158.1, ENSRNOT00000162040.1

Conserved Domains (1) summary

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
XM_006230857.3 → XP_006230919.1 RAS guanyl-releasing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006230919.1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd20861
Location:496 → 551

C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
XM_063268263.1 → XP_063124333.1 RAS guanyl-releasing protein 2 isoform X1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1

Related

ENSRNOP00000028646.7, ENSRNOT00000028646.8
XM_063268278.1 → XP_063124348.1 RAS guanyl-releasing protein 2 isoform X1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1
XM_006230855.5 → XP_006230917.1 RAS guanyl-releasing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006230917.1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd20861
Location:496 → 551

C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
XM_063268264.1 → XP_063124334.1 RAS guanyl-releasing protein 2 isoform X1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1
XM_063268283.1 → XP_063124353.1 RAS guanyl-releasing protein 2 isoform X1

UniProtKB/Swiss-Prot

P0C643

UniProtKB/TrEMBL

A6HZH1
XM_039083991.2 → XP_038939919.1 RAS guanyl-releasing protein 2 isoform X2

Conserved Domains (3) summary

smart00147
Location:5 → 242

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00051
Location:285 → 336

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd20861
Location:351 → 406

C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins