Fbxo11 F-box protein 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Fbxo11provided by RGD
Full Name: F-box protein 11provided by RGD
Primary source: RGD:727935
See related: EnsemblRapid:ENSRNOG00000016396 AllianceGenome:RGD:727935
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vit1
Summary: Predicted to enable protein-arginine N-methyltransferase activity; ubiquitin-like ligase-substrate adaptor activity; and ubiquitin-protein transferase activity. Involved in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel and positive regulation of protein catabolic process. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in breast carcinoma and lung non-small cell carcinoma. Orthologous to human FBXO11 (F-box protein 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 130.9), Spleen (RPKM 100.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (12240348..12316223)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (6486761..6562664)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (11662356..11737427, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH140511 (e-PCR)
- UniSTS:222581

RH126790 (e-PCR)
- UniSTS:209350

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box only protein 11

Names: F-box only protein 11-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181631.2 → NP_853662.1 F-box only protein 11

See identical proteins and their annotated locations for NP_853662.1

Status: PROVISIONAL

Source sequence(s)

AY274810

UniProtKB/Swiss-Prot

Q7TSL3

UniProtKB/TrEMBL

A6H9C5

Related

ENSRNOP00000110764.1, ENSRNOT00000165520.1

Conserved Domains (3) summary

pfam12937
Location:73 → 116

F-box-like

pfam13229
Location:580 → 739

Beta_helix; Right handed beta helix region

cl19744
Location:766 → 807

zf-UBR; Putative zinc finger in N-recognin (UBR box)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

12240348..12316223

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112126.2 → XP_038968054.1 F-box only protein 11 isoform X1

UniProtKB/TrEMBL

A0A8L2QBJ7

Related

ENSRNOP00000021998.5, ENSRNOT00000021998.7

Conserved Domains (3) summary

pfam12937
Location:163 → 206

F-box-like

pfam13229
Location:670 → 829

Beta_helix; Right handed beta helix region

cl19744
Location:856 → 897

zf-UBR; Putative zinc finger in N-recognin (UBR box)
XM_039112127.2 → XP_038968055.1 F-box only protein 11 isoform X2

Conserved Domains (3) summary

pfam12937
Location:162 → 205

F-box-like

pfam13229
Location:669 → 828

Beta_helix; Right handed beta helix region

cl19744
Location:855 → 896

zf-UBR; Putative zinc finger in N-recognin (UBR box)
XM_017594113.3 → XP_017449602.1 F-box only protein 11 isoform X4

UniProtKB/Swiss-Prot

Q7TSL3

UniProtKB/TrEMBL

A6H9C5

Conserved Domains (3) summary

pfam12937
Location:73 → 116

F-box-like

pfam13229
Location:580 → 739

Beta_helix; Right handed beta helix region

cl19744
Location:766 → 807

zf-UBR; Putative zinc finger in N-recognin (UBR box)
XM_063261802.1 → XP_063117872.1 F-box only protein 11 isoform X3