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    Vip vasoactive intestinal peptide [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117064, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vipprovided by RGD
    Official Full Name
    vasoactive intestinal peptideprovided by RGD
    Primary source
    RGD:621647
    See related
    EnsemblRapid:ENSRNOG00000018808 AllianceGenome:RGD:621647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    vip/phi27
    Summary
    Enables hormone activity. Involved in several processes, including negative regulation of smooth muscle cell proliferation; positive regulation of endothelial cell proliferation; and positive regulation of penile erection. Located in neuronal cell body. Used to study several diseases, including Parkinsonism; brain ischemia; periodontitis; pulmonary hypertension; and uveitis. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in alcohol use disorder and pulmonary sarcoidosis. Orthologous to human VIP (vasoactive intestinal peptide). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 54.8), Adrenal (RPKM 4.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vip in Genome Data Viewer
    Location:
    1q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (44470232..44478561)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (42064878..42073219)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (42169307..42177582)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene RNA, U6 small nuclear 959 Neighboring gene myc target 1 Neighboring gene uncharacterized LOC120097707 Neighboring gene F-box protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Therapeutic efficacy of vasoactive intestinal peptide in escherichia coli lipopolysaccharide-induced experimental periodontitis in rats. Gürkan A, et al. J Periodontol, 2009 Oct. PMID 19792856
    2. Vasoactive intestinal peptide can modulate immune and endocrine responses during lipopolysaccharide-induced acute inflammation. Bik W, et al. Neuroimmunomodulation, 2004. PMID 15467350
    3. Vasoactive intestinal peptide protects against ischemic brain damage induced by focal cerebral ischemia in rats. Yang J, et al. Brain Res, 2011 Jun 29. PMID 21620378
    4. Formulation design and in vivo evaluation of dry powder inhalation system of new vasoactive intestinal peptide derivative ([R(15, 20, 21), L(17), A(24,25), des-N(28)]-VIP-GRR) in experimental asthma/COPD model rats. Onoue S, et al. Int J Pharm, 2011 May 30. PMID 21419198
    5. Vasoactive intestinal polypeptide, an erectile neurotransmitter, improves erectile function more significantly in castrated rats than in normal rats. Zhang MG, et al. BJU Int, 2011 Aug. PMID 21166748

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury.
      Title: Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury.
    2. Knockdown of miR-19a suppresses gastrointestinal dysmotility diarrhea after TBI by regulating VIP expression.
      Title: Knockdown of miR-19a suppresses gastrointestinal dysmotility diarrhea after TBI by regulating VIP expression.
    3. Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour.
      Title: Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour.
    4. Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats.
      Title: Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats.
    5. VIP could activate neonatal rat primordial follicle through the ERK-mTOR signalling pathway, suggesting a strategy for in vitro primordial follicle recruitment.
      Title: VIP activates primordial follicles of rat through ERK-mTOR pathway in tissue culture.
    6. The expressions of CGRP and VIP were significantly down-regulated in the erectile dysfunction rat model
      Title: [Expressions of calcitonin gene-related peptide and vasoactive intestinal peptide in the penile tissue of the ED rat model and their action mechanisms].
    7. Study shows that sciatic nerve chronic constriction injury that triggers neuropathic pain and persistent disability results in abnormally increased vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide expression in the periaqueductal grey.
      Title: PACAP and VIP expression in the periaqueductal grey of the rat following sciatic nerve constriction injury.
    8. findings indicate that PACAP and VIP can prevent the deleterious effect of Oxygen/Glucose Deprivation on rat neuronal cells.
      Title: The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation.
    9. VIP is an important regulator of cardiovascular and digestive system in physiological and pathological conditions
      Title: Influence of renovascular hypertension on the distribution of vasoactive intestinal peptide in the stomach and heart of rats.
    10. Data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction of IGN through a VPAC1 receptor-dependent mechanism in enterocytes.
      Title: Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (63)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuropeptide hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables type 1 vasoactive intestinal polypeptide receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type 1 vasoactive intestinal polypeptide receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables type 2 vasoactive intestinal polypeptide receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epinephrine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in learning or memory IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of penile erection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prolactin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    VIP peptides
    Names
    vasoactive intestinal polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053991.1 → NP_446443.1  VIP peptides preproprotein

      See identical proteins and their annotated locations for NP_446443.1

      Status: VALIDATED

      Source sequence(s)
      BC158798, CB583853
      UniProtKB/Swiss-Prot
      P01283, Q9QUN1
      UniProtKB/TrEMBL
      A0A090AX27, A0A090BZQ0, A0A1B0GWR8, A6KIN8
      Related
      ENSRNOP00000025477.6, ENSRNOT00000025477.8
      Conserved Domains (1) summary
      pfam00123
      Location:81 → 108
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      44470232..44478561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078200.2 → XP_038934128.1  VIP peptides isoform X3

      UniProtKB/TrEMBL
      A0A1B0GWR8
      Conserved Domains (1) summary
      pfam00123
      Location:81 → 108
      Hormone_2; Peptide hormone

    2. XM_017588692.3 → XP_017444181.1  VIP peptides isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWR8, B0BNF3
      Conserved Domains (1) summary
      pfam00123
      Location:81 → 107
      Hormone_2; Peptide hormone

    3. XM_017588691.3 → XP_017444180.1  VIP peptides isoform X2

      UniProtKB/TrEMBL
      A0A1B0GWR8
      Conserved Domains (1) summary
      pfam00123
      Location:81 → 107
      Hormone_2; Peptide hormone
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01283.2 GenPept UniProtKB/Swiss-Prot:P01283

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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