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    Hccs holocytochrome c synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hccsprovided by RGD
    Official Full Name
    holocytochrome c synthaseprovided by RGD
    Primary source
    RGD:1563855
    See related
    EnsemblRapid:ENSRNOG00000025910 AllianceGenome:RGD:1563855
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563855
    Summary
    Predicted to enable heme binding activity and holocytochrome-c synthase activity. Predicted to be involved in cytochrome c-heme linkage. Predicted to be located in membrane. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 248.9), Muscle (RPKM 151.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hccs in Genome Data Viewer
    Location:
    Xq13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (28505370..28514812)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (24932943..24942376)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (26294028..26303461)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene midline 1 Neighboring gene uncharacterized LOC134484072 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1, pseudogene 1 Neighboring gene Rho GTPase activating protein 6 Neighboring gene amelogenin, X-linked Neighboring gene uncharacterized LOC120099231

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome. Wimplinger I, et al. Am J Hum Genet, 2006 Nov. PMID 17033964, Free PMC Article
    2. Complementation of a yeast CYC3 deficiency identifies an X-linked mammalian activator of apocytochrome c. Schwarz QP, et al. Genomics, 2002 Jan. PMID 11827457
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables holocytochrome-c synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables holocytochrome-c synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytochrome c-heme linkage ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    holocytochrome c synthase
    Names
    holocytochrome c synthetase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191732.1 → NP_001178661.1  holocytochrome c synthase

      See identical proteins and their annotated locations for NP_001178661.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D3ZL85
      Related
      ENSRNOP00000034552.4, ENSRNOT00000037862.7
      Conserved Domains (1) summary
      pfam01265
      Location:9 → 272
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      28505370..28514812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256834.4 → XP_006256896.1  holocytochrome c synthase isoform X1

      See identical proteins and their annotated locations for XP_006256896.1

      UniProtKB/TrEMBL
      D3ZL85
      Conserved Domains (1) summary
      pfam01265
      Location:9 → 272
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase

    2. XM_039099825.1 → XP_038955753.1  holocytochrome c synthase isoform X2

      Conserved Domains (1) summary
      pfam01265
      Location:1 → 182
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase
    Nucleotide Protein Strain
    Heading Accession and Version

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