Khdrbs2 KH RNA binding domain containing, signal transduction associated 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Khdrbs2provided by RGD
Official Full Name: KH RNA binding domain containing, signal transduction associated 2provided by RGD
Primary source: RGD:621738
See related: EnsemblRapid:ENSRNOG00000012284 AllianceGenome:RGD:621738
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Slm1
Summary: Predicted to enable RNA binding activity and protein domain specific binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Orthologous to human KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 36.8) and Testes (RPKM 10.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q21

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (41943029..42449687)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (34447023..34953684)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (39501431..40008707, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLM-1 is a tissue-specific splicing factor whose activity is regulated by tyrosine phosphorylation signals emanating from p59(fyn).
Title: p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	ISO Inferred from Sequence Orthology more info
enables poly(U) RNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: KH domain-containing, RNA-binding, signal transduction-associated protein 2

Names: KH domain containing, RNA binding, signal transduction associated 2; SLM-1; Sam68-like mammalian protein 1; rSLM-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133318.2 → NP_579852.1 KH domain-containing, RNA-binding, signal transduction-associated protein 2

See identical proteins and their annotated locations for NP_579852.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q920F3

UniProtKB/TrEMBL

A6IN86

Related

ENSRNOP00000016579.3, ENSRNOT00000016578.7

Conserved Domains (3) summary

cd02395
Location:61 → 180

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

pfam16274
Location:6 → 57

Qua1; Qua1 domain

pfam16568
Location:271 → 321

Sam68-YY; Tyrosine-rich domain of Sam68

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

41943029..42449687

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082989.2 → XP_038938917.1 KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform X1

Related

ENSRNOP00000100781.1, ENSRNOT00000154861.1

Conserved Domains (3) summary

pfam16274
Location:5 → 57

Qua1; Qua1 domain

pfam16568
Location:271 → 321

Sam68-YY; Tyrosine-rich domain of Sam68

cd22469
Location:54 → 171

KH-I_KHDRBS2; type I K homology (KH) RNA-binding domain found in KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) and similar proteins