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    Sf3a3 splicing factor 3a, subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313583, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sf3a3provided by RGD
    Official Full Name
    splicing factor 3a, subunit 3provided by RGD
    Primary source
    RGD:1308726
    See related
    EnsemblRapid:ENSRNOG00000007629 AllianceGenome:RGD:1308726
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00093
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP; U2-type precatalytic spliceosome; and catalytic step 2 spliceosome. Orthologous to human SF3A3 (splicing factor 3a subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 206.1), Spleen (RPKM 154.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sf3a3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (142246556..142272053)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (136967713..136987345)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (142702721..142722350)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene four and a half LIM domains 3 Neighboring gene uncharacterized LOC120102976 Neighboring gene inositol polyphosphate-5-phosphatase B Neighboring gene metal-regulatory transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114. Chiara MD, et al. Proc Natl Acad Sci U S A, 1994 Jul 5. PMID 8022796, Free PMC Article
    2. Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo. Tanackovic G, et al. Mol Biol Cell, 2005 Mar. PMID 15647371, Free PMC Article
    3. Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. Nesic D, et al. Mol Cell Biol, 2001 Oct. PMID 11533230, Free PMC Article
    4. Structure of the human activated spliceosome in three conformational states. Zhang X, et al. Cell Res, 2018 Mar. PMID 29360106, Free PMC Article
    5. Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. Neubauer G, et al. Nat Genet, 1998 Sep. PMID 9731529

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC116354

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in U2-type prespliceosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor 3A subunit 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025698.1 → NP_001020869.1  splicing factor 3A subunit 3

      See identical proteins and their annotated locations for NP_001020869.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099183
      UniProtKB/TrEMBL
      A0A8I5ZV68, Q4KLI7
      Related
      ENSRNOP00000082385.1, ENSRNOT00000104879.2
      Conserved Domains (2) summary
      COG5188
      Location:2 → 501
      PRP9; Splicing factor 3a, subunit 3 [RNA processing and modification]
      pfam11931
      Location:323 → 500
      DUF3449; Domain of unknown function (DUF3449)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      142246556..142272053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287750.1 → XP_063143820.1  splicing factor 3A subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZV68, Q4KLI7

    2. XM_063287749.1 → XP_063143819.1  splicing factor 3A subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZV68, Q4KLI7
      Related
      ENSRNOP00000010373.4, ENSRNOT00000010373.7
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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