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    Ehbp1l1 EH domain binding protein 1-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309169, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ehbp1l1provided by RGD
    Official Full Name
    EH domain binding protein 1-like 1provided by RGD
    Primary source
    RGD:1563823
    See related
    EnsemblRapid:ENSRNOG00000056038 AllianceGenome:RGD:1563823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within several processes, including enucleation; erythrocyte differentiation; and mitochondrion localization. Orthologous to human EHBP1L1 (EH domain binding protein 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 368.7), Heart (RPKM 300.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ehbp1l1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212423444..212444357, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202994115..203014320, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221061878..221084423, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546344 Neighboring gene mitogen-activated protein kinase kinase kinase 11 Neighboring gene potassium two pore domain channel subfamily K member 7 Neighboring gene family with sequence similarity 89, member B Neighboring gene zinc ribbon domain containing 2 Neighboring gene latent transforming growth factor beta binding protein 3 Neighboring gene SCY1 like pseudokinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within enucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitochondrion localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleus localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EH domain-binding protein 1-like protein 1
    Names
    tangerin

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025117.2 → NP_001020288.2  EH domain-binding protein 1-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001020288.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains an alternate in-frame exon and lacks an alternate in-frame segment compared to variant 2. The resulting isoform (1) contains an alternate internal segment and lacks another alternate internal segment compared to isoform 2.
      Source sequence(s)
      BC129126
      UniProtKB/TrEMBL
      A0A0G2JVJ5, A0A8I6AQR6, A0A9K3Y6X1, A1L1L8, D4A530
      Related
      ENSRNOP00000069509.2, ENSRNOT00000080455.3
      Conserved Domains (3) summary
      pfam00307
      Location:267 → 366
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:610 → 750
      DUF3585; Protein of unknown function (DUF3585)

    2. NM_001129997.1 → NP_001123469.1  EH domain-binding protein 1-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001123469.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A0A0G2K6R8, A6HZ93
      Related
      ENSRNOP00000073917.2, ENSRNOT00000077526.3
      Conserved Domains (3) summary
      pfam00307
      Location:1192 → 1291
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1535 → 1675
      DUF3585; Protein of unknown function (DUF3585)

    3. NM_001270704.1 → NP_001257633.1  EH domain-binding protein 1-like protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001257633.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site at the 3' end of an exon compared to variant 2. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 2.
      Source sequence(s)
      BC129126, BC167745
      UniProtKB/TrEMBL
      A0A8I6AQR6, B3DM88
      Conserved Domains (3) summary
      pfam00307
      Location:432 → 531
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:775 → 915
      DUF3585; Protein of unknown function (DUF3585)

    4. NM_001270705.1 → NP_001257634.1  EH domain-binding protein 1-like protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001257634.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate in-frame exon and lacks an alternate in-frame segment compared to variant 2. The resulting isoform (4) contains an alternate internal segment and lacks another alternate internal segment compared to isoform 2.
      Source sequence(s)
      BC087115, BC129126
      UniProtKB/TrEMBL
      A0A8I6AQR6, Q5PQM3
      Conserved Domains (3) summary
      pfam00307
      Location:255 → 354
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:598 → 738
      DUF3585; Protein of unknown function (DUF3585)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      212423444..212444357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079598.2 → XP_038935526.1  EH domain-binding protein 1-like protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I6AQR6, A6HZ92
      Conserved Domains (4) summary
      PRK12323
      Location:487 → 757
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:717 → 848
      DUF3585; Protein of unknown function (DUF3585)
      cd21255
      Location:370 → 474
      CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

    2. XM_039079584.2 → XP_038935512.1  EH domain-binding protein 1-like protein 1 isoform X8

      Conserved Domains (5) summary
      PTZ00449
      Location:317 → 502
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PRK12323
      Location:622 → 892
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:852 → 983
      DUF3585; Protein of unknown function (DUF3585)
      cd21255
      Location:505 → 609
      CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

    3. XM_039079546.2 → XP_038935474.1  EH domain-binding protein 1-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZY32
      Related
      ENSRNOP00000084078.1, ENSRNOT00000110292.2
      Conserved Domains (4) summary
      PHA03307
      Location:185 → 524
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1551 → 1682
      DUF3585; Protein of unknown function (DUF3585)
      cd21255
      Location:1204 → 1308
      CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

    4. XM_063264374.1 → XP_063120444.1  EH domain-binding protein 1-like protein 1 isoform X5

    5. XM_039079576.2 → XP_038935504.1  EH domain-binding protein 1-like protein 1 isoform X6

      Conserved Domains (4) summary
      PHA03307
      Location:185 → 524
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:893 → 1024
      DUF3585; Protein of unknown function (DUF3585)
      cd21255
      Location:546 → 650
      CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

    6. XM_039079570.2 → XP_038935498.1  EH domain-binding protein 1-like protein 1 isoform X4

      Conserved Domains (4) summary
      PHA03307
      Location:185 → 524
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:954 → 1085
      DUF3585; Protein of unknown function (DUF3585)
      cd21255
      Location:607 → 711
      CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

    7. XM_063264375.1 → XP_063120445.1  EH domain-binding protein 1-like protein 1 isoform X9

    8. XM_039079580.2 → XP_038935508.1  EH domain-binding protein 1-like protein 1 isoform X7

      Conserved Domains (4) summary
      PRK13108
      Location:322 → 480
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:881 → 1012
      DUF3585; Protein of unknown function (DUF3585)
      cd21255
      Location:534 → 638
      CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

    9. XM_039079589.2 → XP_038935517.1  EH domain-binding protein 1-like protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AQR6
      Conserved Domains (4) summary
      PRK12323
      Location:561 → 831
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:791 → 922
      DUF3585; Protein of unknown function (DUF3585)
      cd21255
      Location:444 → 548
      CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

    10. XM_039079603.2 → XP_038935531.1  EH domain-binding protein 1-like protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8I6AQR6
      Conserved Domains (4) summary
      PRK12323
      Location:445 → 715
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:675 → 806
      DUF3585; Protein of unknown function (DUF3585)
      cd21255
      Location:328 → 432
      CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

    11. XM_039079594.2 → XP_038935522.1  EH domain-binding protein 1-like protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I6AQR6
      Conserved Domains (4) summary
      PRK12323
      Location:499 → 769
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:729 → 860
      DUF3585; Protein of unknown function (DUF3585)
      cd21198
      Location:382 → 486
      CH_EHBP; calponin homology (CH) domain found in the EH domain-binding protein (EHBP) family

    12. XM_039079609.2 → XP_038935537.1  EH domain-binding protein 1-like protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A8I6AQR6
      Conserved Domains (4) summary
      PRK12323
      Location:433 → 703
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:663 → 794
      DUF3585; Protein of unknown function (DUF3585)
      cd21255
      Location:316 → 420
      CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

    13. XM_039079561.2 → XP_038935489.1  EH domain-binding protein 1-like protein 1 isoform X3

      Conserved Domains (3) summary
      PHA03307
      Location:185 → 524
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      cd21255
      Location:1204 → 1308
      CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

    14. XM_063264372.1 → XP_063120442.1  EH domain-binding protein 1-like protein 1 isoform X3

    15. XM_039079553.2 → XP_038935481.1  EH domain-binding protein 1-like protein 1 isoform X2

      Conserved Domains (4) summary
      PHA03307
      Location:185 → 524
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam10358
      Location:12 → 164
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      cd21255
      Location:1204 → 1308
      CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins
      cl23748
      Location:1551 → 1583
      DUF3585; Protein of unknown function (DUF3585)

    RNA

    1. XR_005486675.2 RNA Sequence

    2. XR_005486674.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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