U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rasgef1b RasGEF domain family, member 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361238, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rasgef1bprovided by RGD
    Official Full Name
    RasGEF domain family, member 1Bprovided by RGD
    Primary source
    RGD:1562220
    See related
    EnsemblRapid:ENSRNOG00000002345 AllianceGenome:RGD:1562220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562220
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RASGEF1B (RasGEF domain family member 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 130.1), Kidney (RPKM 109.8) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rasgef1b in Genome Data Viewer
    Location:
    14p22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (10164366..10684184)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (9859512..10380044)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (11499692..12028513)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096568 Neighboring gene uncharacterized LOC134481713 Neighboring gene uncharacterized LOC108352713 Neighboring gene uncharacterized LOC134481715 Neighboring gene eukaryotic translation elongation factor 2, pseudogene 3 Neighboring gene uncharacterized LOC134481714 Neighboring gene uncharacterized LOC120096569 Neighboring gene uncharacterized LOC120096570 Neighboring gene PRELI domain containing 1, pseudogene 4 Neighboring gene uncharacterized LOC134481716 Neighboring gene protein kinase cGMP-dependent 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. Yaman E, et al. FEBS J, 2009 Aug. PMID 19645719
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RasGEF domain family, member 1B; ras-GEF domain-containing family member 1B
    Names
    GPIgamma4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432998.1 → NP_001419927.1  RasGEF domain family, member 1B isoform 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZKP1

    2. NM_001433246.1 → NP_001420175.1  RasGEF domain family, member 1B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZKP1, D3ZJN7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      10164366..10684184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599428.3 → XP_017454917.1  ras-GEF domain-containing family member 1B isoform X2

    2. XM_017599427.3 → XP_017454916.1  ras-GEF domain-containing family member 1B isoform X1

    3. XM_017599429.3 → XP_017454918.1  ras-GEF domain-containing family member 1B isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZKP1
      Related
      ENSRNOP00000093715.2, ENSRNOT00000115895.2

    4. XM_063273740.1 → XP_063129810.1  ras-GEF domain-containing family member 1B isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZKP1
      Related
      ENSRNOP00000078329.1, ENSRNOT00000115253.2

    5. XM_002728083.7 → XP_002728129.2  ras-GEF domain-containing family member 1B isoform X5

      Related
      ENSRNOP00000003207.8, ENSRNOT00000003207.8
      Conserved Domains (2) summary
      cd06224
      Location:42 → 167
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:205 → 454
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.